Results 111 to 120 of about 97,962 (296)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Physics basis for the divertor tokamak test facility

Nuclear Fusion
This paper is dealing with the physics basis used for the design of the Divertor Tokamak Test facility (DTT), under construction in Frascati (DTT 2019 DTT interim design report (2019)) Italy, and with the description of the main target plasma scenarios ...
F. Crisanti, R. Ambrosino, M.V. Falessi, L. Gabellieri, G. Giruzzi, G. Granucci, P. Innocente, P. Mantica, G. Ramogida, G. Vlad, R. Albanese, E. Alessi, C. Angioni, P. Agostinetti, L. Aucone, F. Auriemma, B. Baiocchi, L. Balbinot, A. Balestri, T. Barberis, M. Baruzzo, T. Bolzonella, N. Bonanomi, D. Bonfiglio, S. Brezinsek, G. Calabrò, F. Cani, I. Casiraghi, A. Castaldo, C. Castaldo, M. Cavedon, S. Ceccuzzi, F. Cichocki, M. Ciotti, C. Day, C. De Piccoli, G. Dose, E. Emanueli, L. Frassinetti, L. Figini, V. Fusco, E. Giovannozzi, M. Gobbin, F. Koechi, A. Kryzhanovskyy, Y. Li, R. Lombroni, T. Luda, A. Mariani, P. Martin, C. Meineri, A. Murari, P. Muscente, F. Napoli, E. Nardon, R. Neu, M. Nocente, M. Notazio, S. Nowak, L. Pigatto, C. Piron, F. Porcelli, S. Roccella, G. Rubino, M. Scarpari, C. Sozzi, G. Spizzo, F. Subba, F. Taccogna, C. Tantos, D. Terranova, E. Tsitrone, A. Uccello, D. Van Eester, N. Vianello, P. Vincenzi, M. Wischmeier, F. Zonca   +77 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Constructing sports facilities using environment-friendly materials

Frontiers in Materials
This study is focused on applying environment-friendly materials (EFM) to construct sports facilities for sustainability. The current status and future potential of using EFM in sports facility construction are concretely discussed with a thorough ...
Rui Li, Chenxi Zhai
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Uncovering ‘Weak signals’ through patient journey mapping to inform the future redesign of the medical consultation room

BMC Health Services Research
Background Designing hospital environments requires balancing functional efficiency with patient-centered care. Subtle environmental and procedural frictions, often overlooked in traditional evaluations, can significantly affect patient experiences. This
Ana S. Cunha, João V. Cordeiro, Guilherme Victorino   +2 more
doaj   +1 more source

Assessing the Digital Transformation Readiness of the Construction Industry Utilizing the Delphi Method

Buildings
The rapid advancement of digital technology has enabled digital transformation across various sectors, including construction. The construction industry has long been associated with conventional, labor-intensive practices that can adversely influence ...
Khalid K. Naji, Murat Gunduz, Fahid Alhenzab, Hamed Al-Hababi, Abdulla Al-Qahtani   +4 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source