Results 131 to 140 of about 710,173 (345)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Physics basis for the divertor tokamak test facility

Nuclear Fusion
This paper is dealing with the physics basis used for the design of the Divertor Tokamak Test facility (DTT), under construction in Frascati (DTT 2019 DTT interim design report (2019)) Italy, and with the description of the main target plasma scenarios ...
F. Crisanti, R. Ambrosino, M.V. Falessi, L. Gabellieri, G. Giruzzi, G. Granucci, P. Innocente, P. Mantica, G. Ramogida, G. Vlad, R. Albanese, E. Alessi, C. Angioni, P. Agostinetti, L. Aucone, F. Auriemma, B. Baiocchi, L. Balbinot, A. Balestri, T. Barberis, M. Baruzzo, T. Bolzonella, N. Bonanomi, D. Bonfiglio, S. Brezinsek, G. Calabrò, F. Cani, I. Casiraghi, A. Castaldo, C. Castaldo, M. Cavedon, S. Ceccuzzi, F. Cichocki, M. Ciotti, C. Day, C. De Piccoli, G. Dose, E. Emanueli, L. Frassinetti, L. Figini, V. Fusco, E. Giovannozzi, M. Gobbin, F. Koechi, A. Kryzhanovskyy, Y. Li, R. Lombroni, T. Luda, A. Mariani, P. Martin, C. Meineri, A. Murari, P. Muscente, F. Napoli, E. Nardon, R. Neu, M. Nocente, M. Notazio, S. Nowak, L. Pigatto, C. Piron, F. Porcelli, S. Roccella, G. Rubino, M. Scarpari, C. Sozzi, G. Spizzo, F. Subba, F. Taccogna, C. Tantos, D. Terranova, E. Tsitrone, A. Uccello, D. Van Eester, N. Vianello, P. Vincenzi, M. Wischmeier, F. Zonca   +77 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Assessing the Digital Transformation Readiness of the Construction Industry Utilizing the Delphi Method

Buildings
The rapid advancement of digital technology has enabled digital transformation across various sectors, including construction. The construction industry has long been associated with conventional, labor-intensive practices that can adversely influence ...
Khalid K. Naji, Murat Gunduz, Fahid Alhenzab, Hamed Al-Hababi, Abdulla Al-Qahtani   +4 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Constructing sports facilities using environment-friendly materials

Frontiers in Materials
This study is focused on applying environment-friendly materials (EFM) to construct sports facilities for sustainability. The current status and future potential of using EFM in sports facility construction are concretely discussed with a thorough ...
Rui Li, Chenxi Zhai
doaj   +1 more source

Conceptual design study for an advanced cab and visual system, volume 2 [PDF]

The performance, design, construction and testing requirements are defined for developing an advanced cab and visual system. The rotorcraft system integration simulator is composed of the advanced cab and visual system and the rotorcraft system motion ...
Cyrus, M. L., Garnett, T. A., Nachbor, J. W., Rue, R. J., Seery, J. A., Starr, R. L.   +5 more
core   +1 more source

Testing a Personalized Approach to Chronic Low Back Pain: A Randomized Controlled Trial in Older Veterans

Arthritis Care &Research, EarlyView.
Objective We aimed to test the efficacy of personalized treatment of older veterans with chronic low back pain (CLBP) delivered by Aging Back Clinics (ABCs) as compared with usual care (UC). Methods Two hundred ninety‐nine veterans aged 65 to 89 with CLBP from three Veterans Affairs (VA) medical centers underwent baseline testing, randomization to ABC ...
Debra K. Weiner, Angela Gentili, Meika A. Fang, Edward Garay, Laura Lawson, Lenore Joseph, Cathy C. Lee, Michelle I. Rossi, Beverly Thorn, Subashan Perera   +9 more
wiley   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Uncovering ‘Weak signals’ through patient journey mapping to inform the future redesign of the medical consultation room

BMC Health Services Research
Background Designing hospital environments requires balancing functional efficiency with patient-centered care. Subtle environmental and procedural frictions, often overlooked in traditional evaluations, can significantly affect patient experiences. This
Ana S. Cunha, João V. Cordeiro, Guilherme Victorino   +2 more
doaj   +1 more source