Results 31 to 40 of about 71,380 (259)

A new GA based solution for capacitated multi source Weber problem Nazila Mohammadi [PDF]

International Journal of Computational Intelligence Systems, 2010
The main purpose of any facility location is to select the optimal places that satisfy project's goals. In location problems, the object is usually to optimize a function - objective function - that defines the problem conditions and efficient decision ...
Nazila Mohammadi, Mohammad Reza Malek, Ali Asghar Alesheikh   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Survey of Approximation Algorithms for the Universal Facility Location Problem

Mathematics
The facility location problem is a classical combinatorial optimization problem with extensive applications spanning communication technology, economic management, traffic governance, and public services.
Hanyin Xiao, Jiaming Zhang, Zhikang Zhang, Weidong Li   +3 more
doaj   +1 more source

Logistic model for the facility location problem on ellipsoids

International Journal of Engineering Business Management, 2016
The facility location problem (FLP) consists of finding the best location for a facility (service center) to efficiently meet the demands of client points. Studies on the FLP have considered flat or spherical surfaces for computation of distances between
Lucia Cazabal-Valencia, Santiago-Omar Caballero-Morales, José-Luís Martínez-Flores   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A competitive facility location in a closed form supply chain [PDF]

Decision Science Letters, 2014
This paper studies capacitated facility location problem by considering green management perspectives. The proposed study considers reverse logistic problem as an alternative strategy for facility location in an attempt to take care of environmental ...
Mohammad Ali Mohammadi, Hamid Davoudpour, Zahra Motamedi   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Facility Location Problem

, 2017
Σκοπός της διπλωματικής εργασίας ήταν η μελέτη χωροθέτησης των εγκαταστάσεων. Ανέφερα γενικές πληροφορίες, ορισμούς για τα logistics και Supply chain management, καθώς και την βιβλιογραφική ανασκόπηση για την χωροθέτηση εγκαταστάσεων και για τα προβλήματα χωροθέτησης εγκαταστάσεων. Στη συνέχεια ανέφερα ορισμένες ταξινομήσεις των προβλημάτων χωροθέτησης
  +5 more sources

A simulation based research on chance constrained programming in robust facility location problem

Open Physics, 2017
Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling.
Kaijun Leng, Wen Shi, Guanghua Song, Lin Pan   +3 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source