Results 41 to 50 of about 76,976 (306)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

GIS Exploitation for New Facility Location Decisions- A Logistics Perspective [PDF]

Journal of International Logistics and Trade, 2012
Logistical facility location decisions can make a crucial difference in the success or failure of a company. Geographical Information Systems (GIS) have recently become a very popular decision support system to help deal with facility location problems ...
Afzal Mohammad Khaled, Yong Jin Kim
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Nash Welfare in the Facility Location Problem [PDF]

Proceedings of the Thirtieth International Joint Conference on Artificial Intelligence, 2021
In most facility location research, either an efficient facility placement which minimizes the total cost or a fairer placement which minimizes the maximum cost are typically proposed. To find a solution that is both fair and efficient, we propose converting the agent costs to utilities and placing the facility/ies such that the product of utilities ...
openaire   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A Hybrid Approach for The Design of Facility Location and Supply Chain Network Under Supply and Demand Uncertainty: A Systematic Review [PDF]

, 2009
In today’s extremely competitive marketplace, firms are facing the need to meet or exceed increasing customer expectations while cutting costs to stay competitive in a global market. To develop competitive advantage in this business climate, companies
Meeyai, Sutthipong
core  

An Optimization Model for Advanced Life Support Ambulance Facility Location Problem

Proceedings, 2020
The survival rate of the patients in medical emergencies depends on the minimize ambulance arrival time on-sites and promptly provides medical care to the patients.
Detcharat Sumrit, Kamonchanok Thongsiriruengchai   +1 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Primal-dual variable neighborhood search for the simple plant-location problem

, 2007
Copyright @ 2007 INFORMSThe variable neighborhood search metaheuristic is applied to the primal simple plant-location problem and to a reduced dual obtained by exploiting the complementary slackness conditions.
Brimberg, J, Hansen, P, Urosevic, D, Mladenović, N   +3 more
core   +1 more source

Optimizing business location for small and medium enterprises considering travel time uncertainty, natural disasters, and density population: a study case in Jakarta

Jurnal Sistem dan Manajemen Industri
This study addresses the critical problem of identifying optimal business locations for small and medium enterprises (SMEs), a decision-making process by factors such as travel time uncertainty, natural disasters, and population density.
Herman Sjahruddin, Ahmad Faisal Dahlan
doaj   +1 more source