Results 161 to 170 of about 3,740,163 (314)

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors

Advanced Science, EarlyView.
A biodegradable molecularly imprinted polymer porous silica sensor enables dual optical readout of doxorubicin via fluorescence and effective optical thickness shifts. The combined transduction mechanisms provide enhanced reliability and quantitative accuracy over clinically relevant concentrations, representing a step toward transient implantable ...
Martina Corsi, Tiziano Di Giulio, Eleonora Vandini, Muhammad Ibrar Asif, Eleonora Daini, Antonietta Vilella, Giuseppina Leo, Alessandra Ottani, Cosimino Malitesta, Daniela Giuliani, Elisabetta Mazzotta, Giuseppe Barillaro   +11 more
wiley   +1 more source

Interfacial Polysulfide Confinement via Spatially Controlled Sulfonated Metal–Organic Polyhedra Coatings in Lithium–Sulfur Batteries

Advanced Science, EarlyView.
Spatially controlled sulfonated metal–organic polyhedra (SMOP) coating on sulfur‐loaded hollow carbon spheres form ultrathin, conformal interfacial barriers that selectively confine soluble polysulfides, stabilize sulfur redox, and suppress shuttle reactions.
Soyeon Ko, WooYeon Moon, Yuwei Zhu, Yuhui An, Yunyuan Lu, Sourayan Bal, Linqin Mu, Kyung Min Choi, Yoon Hwa   +8 more
wiley   +1 more source

Reaction‐Induced Reversible Reconstruction Enhanced Ni‐MgO/CaO Dual Functional Material for Stable CO2 Capture and In Situ Conversion

Advanced Science, EarlyView.
A highly dispersed NiO‐MgO solid solution (MgxNi1‐xO) is created in a hierarchically porous Ca‐based matrix to protect Ni and CaO nanoparticles against carbon deposition and sintering. Owing to the reversible reconstruction of MgxNi1‐xO, this superior structure is self‐regenerative in the calcium looping dry reforming of methane process, thereby ...
Hao Xu, Chen Hou, Jiawei Zhong, Chuande Huang, Wei Wei, Jiawei Hu   +5 more
wiley   +1 more source