Results 91 to 100 of about 3,069,910 (243)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Basic emotions expressed in music: factor analyses on intensity ratings by non-musical professional Chinese university students

Psychology Research and Behavior Management, 2018
Chanchan Shen,1 Mufan Wang,2 Tongjun Ding,3 Yang Yang,4 Javier Cabanyes-Truffino,5 Lijun Sun,6 Chu Wang,1 Wei Wang1 1Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China ...
Shen C, Wang M, Ding T, Yang Y, Cabanyes-Truffino J, Sun L, Wang C, Wang W   +7 more
doaj  

Longitudinal validation of cognitive reserve proxy measures: a cohort study in a rural Chinese community

Alzheimer’s Research & Therapy
Background While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, including later-life factors, remains scarce.
Hao Chen, Jin Hu, Shiqi Gui, Qiushuo Li, Jing Wang, Xing Yang, Jingyuan Yang   +6 more
doaj   +1 more source

Treatment paradigm and prognostic factor analyses of rectal squamous cell carcinoma. [PDF]

Front Oncol, 2023
Liu R, Zhang J, Zhang Y, Yan J.
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Measuring relational wellbeing: construct validity in pre-COVID-Era UK; generalizability across COVID-lockdown-Era India, Greece, and UK

Frontiers in Psychology
AimIn the present studies, we examine the construct validity and criterion-related validity of a previously unpublished, eight-item measure of relational wellbeing.MethodsFirst, in two pre-COVID-Era pilot studies within the UK (n’s = 207 and 146 ...
Stanley O. Gaines, Pauldy Otermans, Pauldy Otermans, Maria Spanoudaki, Dev Aditya, Dev Aditya, Netsai Chirenda   +6 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

The relationships between dietary patterns and socioeconomic status with anthropometric and body composition indices in Iranian preschool children: A cross‐sectional study

Obesity Science & Practice
Background The prevalence of overweight and obesity among Iranian children is on the rise. Dietary patterns (DPs) and socioeconomic status ( socioeconomic status (SES)) may relate to children's excess weight as a predictor of the risk of obesity in ...
Elyas Nattagh‐Eshtivani, Naseh Pahlavani, Maryam Khosravi, Somayeh Pourhosein Sarivi, Atieh Mehdizadeh Hakkak, Mona Maddahi   +5 more
doaj   +1 more source