Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Analysis and evaluation of the image of Adelais silk scarf based on grey correlation
In order to investigate the continuation and innovation of Adelais culture in contemporary fashion and explore the effective application of Adelais silk patterns in scarves, this study meticulously selected 13 representative Adelais silk patterns from ...
GU Zhaohui, HU Siqi
doaj +1 more source
Application of factor analysis in the typology of agriculture in Serbia [PDF]
Factor analysis was used as a method for determining the types of agriculture in Serbia, which resulted in the synthesised and comprehensive data presented in the study.
Mihajlović Ljiljana +3 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Rainfall warning Based on indexs teleconnection, Synoptic Patterns of Atmospheric Upper Levels and Climatic elements a case study of Karoun basin [PDF]
Rainfall prediction plays an important role in flood management and flood alert. With rainfall information, it is possible to predict the occurrence of floods in a given area and take the necessary measures.
iran salehvand +2 more
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Dimensions of Grace: Factor Analysis of Three Grace Scales
Measuring grace is challenging. Prior research found the Grace Scale (GS), Richmont Grace Scale (RGS), and The Amazing Grace Scale (TAGS) to be reliable, have promising convergent and divergent validity, and to inter-correlate strongly. However, they may
Blackburn, Amanda M. +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The influence of students’ engagement in mathematical problem solving activities
The ability to retain and sustain students’ engagement in mathematics is crucial for fostering a lifelong interest in a subject that often turns students off. Problem-solving techniques are dynamic, particularly when integrated into teaching and learning
Olajumoke Olayemi Salami +1 more
doaj +1 more source

