Results 111 to 120 of about 6,103,116 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Determination of accident causation and risk factors in traffic accidents from the point of view of motorcyclist users [PDF]

, 2012
The Powered Two Wheelers (PTWs) accidents constitute one of the road safety targets in Europe. PTWs users' fatalities represent 15% of EU road fatalities, having increased the last few years, which is quite opposite than other road users casualties.
Molinero, A., Martin, O., Mansilla, A., Perandones, J.M., Pedrero, D.   +4 more
core  

Clustering, Classification, and Factor Analysis in High Dimensional Data Analysis

, 2016
Clustering, classification, and factor analysis are three popular data mining techniques. In this dissertation, we investigate these methods in high dimensional data analysis.
Wang, Yanhong
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Motor skills in the structure of motor readiness of karate athletes 9 years old (using the example of the «Yoko geri chudan» kick)

Слобожанський науково-спортивний вісник
Purpose of the study – to determine the place of motor skills in the structure of motor training of 9-year-old karate boys in the process of learning «Yoko geri chudan» side kick. Materials and methods. The study involved 32 boys aged 9.
Svitlana Marchenko
doaj   +1 more source

The impact of factor score extraction method for exploratory factor analysis on resultant factor scores and links to behaviour in a cognitive task across independent samples differing in underlying correlation structure

For factor analysis, the link between factors and factor scores (i.e. the score each person has for a factor) is not unique. Therefore, there are different methods that have been proposed for extracting factor scores.
Jacqueline Scholl
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Psychological characteristics of the rural poor from self-assessment and external assessment perspectives and their association with socio-demographic factors

Frontiers in Psychology
ObjectiveThis study aims to explore the differences in psychological traits between rural poor individuals from self-assessment and external assessment perspectives, and to examine the correlation between the main socio-demographic factors of the poor ...
Wei Wei, Wei Wei, Yan Li, Jinwei Zhu
doaj   +1 more source