Results 91 to 100 of about 4,680,194 (246)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain

International Journal of Women's Health, 2013
Hugo Maia Jr,1–3 Clarice Haddad,3 Julio Casoy3 1Department of Gynecology and Obstetrics, School of Medicine, Federal University of Bahia, 2Itaigara Memorial Day Hospital, 3Centro de Pesquisas e Assistência em Reprodução Humana ...
Maia H Jr, Haddad C, Casoy J
doaj  

The effectiveness and safety of various treatments for hemophilia in China: a literature review and evidence mapping

Hematology
To evaluate the safety and effectiveness of treatments for hemophilia in China through a literature review and evidence mapping, we systematically searched PubMed, Web of Science, Cochrane Library, CNKI, Wanfang, and CBM. Descriptive statistics were used
Yu Yang, Jing Zhang, Lingling Chen, Huan Dong, Ting Sun, Xinyue Dai, Mankai Ju, Wei Liu, Yunfei Chen, Xiaofan Liu, Rongfeng Fu, Lei Zhang, Feng Xue, Renchi Yang   +13 more
doaj   +1 more source

Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion. [PDF]

World J Diabetes, 2023
Li YQ, Zhang LY, Zhao YC, Xu F, Hu ZY, Wu QH, Li WH, Li YN.   +7 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Manejo, prevención y control de la anemia perniciosa Management, prevention and control of pernicious anemia

Nutrición Hospitalaria, 2005
La anemia perniciosa es la causa más frecuente de anemia megaloblástica en nuestro medio y es consecuencia de una deficiencia de vitamina B12 debido a su vez a la disminución o ausencia de factor intrínseco (FI) por atrofia de la mucosa gástrica o por ...
R. De Paz, F. Hernández-Navarro
doaj  

Factor B Mutation in Monozygotic Twins Discordant for Atypical Hemolytic Uremic Syndrome. [PDF]

Kidney Int Rep, 2023
Aradottir SS, Kristoffersson AC, Jensson BO, Sulem P, Gong H, Palsson R, Karpman D.   +6 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Computer-aided identification of Mycobacterium tuberculosis resuscitation-promoting factor B (RpfB) inhibitors from Gymnema sylvestre natural products. [PDF]

Front Pharmacol, 2023
Shah M, Khan F, Ahmad I, Deng CL, Perveen A, Iqbal A, Nishan U, Zaman A, Ullah R, Ali EA, Chen K.   +10 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source