Results 91 to 100 of about 2,000,070 (348)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes [PDF]

, 1991
We have used a recently characterized rabbit antiserum against basic fibroblast growth factor (bFGF), which recognizes various forms of bFGF, to examine the presence and localization of bFGF in the testes of adult rats and mice and the 5-day-old rat.
Gratzl, Manfred, Grothe, C., Mayerhofer, Artur, Rudolf, M., Russell, J. T.   +4 more
core   +1 more source

Six-body calculation of the alpha-deuteron radiative capture cross section

, 2000
We have computed the cross section for the process d + alpha -> 6Li + gamma at the low energies relevant for primordial nucleosynthesis and comparison with laboratory data.
Nollett, K. M., Schiavilla, R., Wiringa, R. B.   +2 more
core   +1 more source

Planar inviscid flows in a channel of finite length : washout, trapping and self-oscillations of vorticity [PDF]

, 2010
The paper addresses the nonlinear dynamics of planar inviscid incompressible flows in the straight channel of a finite length. Our attention is focused on the effects of boundary conditions on vorticity dynamics.
Govorukhin, V. N., Morgulis, A. B., Vladimirov, V. A.   +2 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

X-Linked Thrombophilia with a Mutant Factor IX (Factor IX Padua)

New England Journal of Medicine, 2009
We report a case of juvenile thrombophilia associated with a substitution of leucine for arginine at position 338 (R338L) in the factor IX gene (factor IX-R338L). The level of the mutant factor IX protein in plasma was normal, but the clotting activity of factor IX from the proband was approximately eight times the normal level.
SIMIONI, PAOLO, TORMENE, DANIELA, TOGNIN G, GAVASSO, SABRINA, BULATO, CRISTIANA, IACOBELLI NP, FINN JD, SPIEZIA, LUCA, RADU, CLAUDIA-MARIA, ARRUDA VR   +9 more
openaire   +3 more sources

THE EFFECT OF ADDITIONAL FASILITY FOR STUDY BASED ON ANIMATION TO THE RESULT IN STUDYING AUDIO MIXER SPECIALLY IN AUDIO VIDEO IN SMK PIRI 1 YOGYAKARTA [PDF]

, 2012
This study was done to know the effect of animation media to the result of students studies in Audio Mixer and to know the increasing of the result of the student study in SMK PIRI 1 Yogyakarta specially in the IX class after using the animation media ...
Nunik, Solichatun
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Protein-Engineered Coagulation Factors for Hemophilia Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2019
Hemophilia A (HA) and hemophilia B (HB) are X-linked bleeding disorders due to inheritable deficiencies in either coagulation factor VIII (FVIII) or factor IX (FIX), respectively.
Benjamin J. Samelson-Jones, Valder R. Arruda   +1 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source