Results 271 to 280 of about 2,000,070 (348)

A novel snake venom C-type lectin-like protein modulates blood coagulation by targeting von Willebrand factor and coagulation factor IX. [PDF]

Sci Rep
Zeng FY, Ji RS, Yu XQ, Li YN, Zhang QY, Sun QY.   +5 more
europepmc   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Enhanced procoagulant activity of select hemophilia B causing factor IX variants with emicizumab.

Blood
Lee K, Chau JQ, Suber YB, Sternberg AR, Pishko AM, George LA, Bhoj VG, Doshi BS, Samelson-Jones BJ.   +8 more
europepmc   +1 more source

Assessing health care resource use, outcomes, and costs among Medicaid beneficiaries receiving factor IX prophylaxis for hemophilia B. [PDF]

J Manag Care Spec Pharm
Pauly N, Burrell A, Drelich D, Zhang X, Thiruvillakkat K, Nysenbaum J, Fiori A, Yan S.   +7 more
europepmc   +1 more source

Meta‐Rod Mechanical Metamaterials With Programmable Reconfiguration

Advanced Functional Materials, EarlyView.
Existing mechanical metamaterials achieve programmable large deformations in planar square or cubic configurations, restricted by required complex boundary conditions. This research proposes a 1D metamaterial, Meta‐rod, with linear, bending, twisting, area, and volume deformation modes.
Atharva Pande, Lyes Kadem, Hang Xu
wiley   +1 more source

The impact of capping health system cost savings on the projected cost-effectiveness of etranacogene dezaparvovec compared with factor IX prophylaxis for the treatment of hemophilia B. [PDF]

J Manag Care Spec Pharm
Sarker J, Tice JA, Rind DM, Pearson SD, Walton SM.   +4 more
europepmc   +1 more source

3D‐Printed Porous Hydroxyapatite Formed via Enzymatic Mineralization

Advanced Functional Materials, EarlyView.
Bone combines lightness, strength, and the ability to heal, inspiring new materials design. This work introduces a room‐temperature, enzyme‐mediated 3D printing method to create porous hydroxyapatite scaffolds. The process avoids energy‐intensive sintering, preserves bioactivity, and allows control over porosity and mineralization.
Francesca Bono, Anna Puiggalí‐Jou, Greta Cocchi, Mariangela Miccoli, Katharina Maniura‐Weber, Marcy Zenobi‐Wong, Esther Amstad   +6 more
wiley   +1 more source

Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human factor IX variant in mice and rhesus macaques. [PDF]

Mol Ther
Pekrun K, Stephens CJ, Gonzalez-Sandoval A, Goswami A, Zhang F, Tarantal AF, Blouse G, Kay MA.   +7 more
europepmc   +1 more source

Copper‐Based Crystalline‐Metallic Glass Composite Thin Films: A Novel Material with Enhanced Strength and Thermally Stable Nanotwins

Advanced Functional Materials, EarlyView.
A Cu‐based crystal‐glass composite with high‐density twins is identified by a fast screening technique using combinatorial sputtering together with XRD and nanoindentation mapping. This bamboo‐like structure demonstrates homogenous plastic flow and retains high strength during in situ high temperature tests, up to 1 GPa at 550°C, owing to those ...
Chunhua Tian, Amit Sharma, Krzysztof Wieczerzak, Alexander Groetsch, Manish Jain, Nicolò Maria della Ventura, Remo Widmer, Fedor F. Klimashin, Johann Michler, Jakob Schwiedrzik, Xavier Maeder   +10 more
wiley   +1 more source

Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction. [PDF]

J Thromb Haemost
Coyle CW, Knight KA, Brown HC, George SN, Denning G, Branella GM, Childers KC, Spiegel PC, Spencer HT, Doering CB.   +9 more
europepmc   +1 more source