Results 321 to 330 of about 14,184,553 (374)

The Activation and Consumption of Factor IX

Thrombosis and Haemostasis, 1964
Discussion and ConclusionsThe results of these experiments support previous observations that factor IX activity is increased approximately ten fold by incubation with calcium and optimal amounts of product XI a. The finding of a reciprocal relationship between maximal product IX a formation and residual factor IX provides further evidence in favour of
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[6] Human factor IX and factor IXa

1993
Publisher Summary This chapter provides methods for factor IX and factor IXa isolation from human plasma and recombinant cultures and discusses the preparation of [ 3 H]sialyl and of 125 I-labeled tyrosyl factor IX and their use in investigations of the structure-function relationships in the protein.
S P Bajaj, J J Birktoft
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Measurement of Activated Factor IX in Factor IX Concentrates: Correlation with In Vivo Thrombogenicity

Thrombosis and Haemostasis, 1995
SummaryCurrent in vitro tests for thrombogenicity of FIX concentrates used for prothrombin complex concentrates (PCCs), are of little value when applied to high purity FIX (HP FIXs). In the present study, we have developed a chromogenic assay for activated FIX (FIXa) and evaluated its ability to predict in vivo thrombogenic potential of HP FIXs in a ...
M Boisclair, Trevor W Barrowcliffe, A Oates, G Kemball-Cook, S Thomas, Jill Tubbs, Elaine Gray   +6 more
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Properties of Factor IX Concentrates

Acta Haematologica, 1995
Five purified concentrates--Nanotiv (Kabi Pharmacia), Immunine (Immuno), Factor IX VHP (Biotransfusion), Alphanine (Alpha Therapeutic Corporation), and Mononine (Armour Pharmaceutical Company)--were characterized biochemically and their in vivo pharmacokinetic and thrombogenic properties evaluated.
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[8] Bovine factor IX (christmas factor)

1976
Publisher Summary Factor IX is a plasma glycoprotein that participates in the middle phase of intrinsic blood coagulation. It is inactive or absent in the plasma of individuals with a congenital bleeding disorder known as Christmas disease or hemophilia B.
Earl W. Davie, Kazuo Fujikawa
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Nucleotide sequence of the gene for human factor IX (antihemophilic factor B).

Biochemistry, 1985
Two different human genomic DNA libraries were screened for the gene for blood coagulation factor IX by employing a cDNA for the human protein as a hybridization probe. Five overlapping lambda phages were identified that contained the gene for factor IX.
S. Yoshitake, B. Schach, D. Foster, E. Davie, K. Kurachi   +4 more
semanticscholar   +1 more source

Cellular activation of factor IX (christmas factor)

Thrombosis Research, 1978
Abstract We have demonstrated Factor IX activation by sonicated polymorphonuclear leukocytes (PMNs). This activation reaction required the disrupted leukocytes, calcium chloride, and a small amount of normal human plasma. The requirement for normal plasma was met by plasma deficient in all of the known coagulation factors, and thus the substance ...
Henry S. Kingdon, P. Gregory Rausch, John C. Herion   +2 more
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Prevalence of Factor IX-R338L (Factor IX Padua) in a cohort of patients with venous thromboembolism and mild elevation of factor IX levels

Thrombosis Research, 2009
Abstract Abstract 5057 Introduction Elevated plasma levels of blood coagulation factor IX (FIX) have been associated with increased risk of venous thromboembolism (VTE) in humans. However, the molecular mechanisms underlying elevated FIX have not been elucidated. Recently, a mutation in
Fernanda Andrade Orsi, Erich Vinicius De Paula, Bruna M Mazetto, Lucia H. Siqueira, Tayana B. T. Mello, Joyce M. Annichino-Bizzacchi   +5 more
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A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S.

Biochemistry, 1977
Human prothrombin, factor IX, and factor X have been idolated in high yield and characterized as the their amino-terminal sequence, molecular weight, amino acid composition, and migration in sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
R. Scipio, M. Hermodson, Stanley G. Yates, E. Davie   +3 more
semanticscholar   +1 more source

Factor IX Concentrates

2009
Publisher Summary This chapter describes Factor IX (FIX) concentrates, which are either manufactured from human plasma pools or genetically engineered and FIX concentrates are indicated in treatment of hemophilia B. There are currently two plasma derived FIX concentrates available; AlphaNine SD and Mononine.
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