Results 41 to 50 of about 14,538,270 (379)

X-Linked Thrombophilia with a Mutant Factor IX (Factor IX Padua)

New England Journal of Medicine, 2009
We report a case of juvenile thrombophilia associated with a substitution of leucine for arginine at position 338 (R338L) in the factor IX gene (factor IX-R338L). The level of the mutant factor IX protein in plasma was normal, but the clotting activity of factor IX from the proband was approximately eight times the normal level.
SIMIONI, PAOLO, TORMENE, DANIELA, TOGNIN G, GAVASSO, SABRINA, BULATO, CRISTIANA, IACOBELLI NP, FINN JD, SPIEZIA, LUCA, RADU, CLAUDIA-MARIA, ARRUDA VR   +9 more
openaire   +4 more sources

A computer‐based model to assess costs associated with the use of factor VIII and factor IX one‐stage and chromogenic activity assays

Journal of Thrombosis and Haemostasis, 2016
Essentials Chromogenic factor VIII and factor IX assays have not been widely adopted partly due to perceived cost. Chromogenic assays may be needed for monitoring therapy with some extended half‐life concentrates.
S. Kitchen, J. Blakemore, K. Friedman, D. Hart, R. Ko, R. Ko, D. Perry, S. Platton, D. Tan-Castillo, G. Young, G. Young, R. Luddington   +11 more
semanticscholar   +1 more source

Weak proton capture on 3He [PDF]

, 2000
The astrophysical S-factor for the proton weak capture on 3He is calculated with correlated-hyperspherical-harmonics bound and continuum wave functions corresponding to realistic Hamiltonians consisting of the Argonne v14 or Argonne v18 two-nucleon and ...
Beacom, J. F., Kievsky, A., Marcucci, L. E., Rosati, S., Schiavilla, R., Viviani, M.   +5 more
core   +2 more sources

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. [PDF]

, 2001
Long-term expression of coagulation factor IX (FIX) has been observed in murine and canine models following administration of recombinant adeno-associated viral (rAAV) vectors into either the portal vein or muscle. These studies were designed to evaluate
Davidoff, A, Hanawa, H, Nathwani, AC, Nienhuis, AW, Vanin, EF, Zhou, JF   +5 more
core   +1 more source

Gene Therapy and Hemophilia: Where Do We Go from Here?

Journal of Blood Medicine, 2022
Nancy S Bolous,1 Nidhi Bhatt,2 Nickhill Bhakta,1 Ellis J Neufeld,2 Andrew M Davidoff,3 Ulrike M Reiss2 1Department of Global Pediatric Medicine – St.
Bolous NS, Bhatt N, Bhakta N, Neufeld EJ, Davidoff AM, Reiss UM   +5 more
doaj  

Results of a phase I/II open-label, safety and efficacy trial of coagulation factor IX (recombinant), albumin fusion protein in haemophilia B patients

Haemophilia, 2015
rIX‐FP is a coagulation factor IX (recombinant), albumin fusion protein with more than fivefold half‐life prolongation over other standard factor IX (FIX) products available on the market.
U. Martinowitz, T. Lissitchkov, A. Lubetsky, G. Jotov, Tami Barazani-Brutman, Christine Voigt, Iris Jacobs, T. Wuerfel, Elena Santagostino   +8 more
semanticscholar   +1 more source

Billiard representation for multidimensional multi-scalar cosmological model with exponential potentials

, 2003
Multidimensional cosmological-type model with n Einstein factor spaces in the theory with l scalar fields and multiple exponential potential is considered.
Dehnen, H., Ivashchuk, V. D., Melnikov, V. N.   +2 more
core   +1 more source

Beware of Reversal of an Anticoagulated Patient with Factor IX in the Emergency Department: Case Report of a Medical-Legal Misadventure

Clinical Practice and Cases in Emergency Medicine, 2020
In this article we present a case of a patient who received reversal of anticoagulation therapy with factor IX in violation of hospital guidelines. As a direct result, myocardial infarction and ischemic stroke occurred, leaving the patient neurologically
Steven Gannon, David Bell, Kenneth Jackmiczyk, Gregory Moore   +3 more
doaj   +1 more source

TREATMENT OF HEMOPHILIA WITH HUMAN FACTORIX PRODUCED IN MAMIMARY TISSUE OF TRANSGENIC MAMMALS [PDF]

, 2008
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention.
Drohan, William N., Johnson, John L., Johnson, Mary Ann H., Lubon, Henryk, Velander, William H.   +4 more
core   +1 more source

Metabolic, inflammatory and haemostatic effects of a low-dose continuous combined HRT in women with type 2 diabetes: potentially safer with respect to vascular risk? [PDF]

, 2003
BACKGROUND Conventional hormone replacement therapy (HRT) containing conjugated equine oestrogen (CEE) and medroxyprogesterone acetate (MPA) increases triglyceride, C- reactive protein (CRP) and coagulation Factor VII concentrations, potentially ...
Alan J. Jaap, Andersen, Anderson, Ann Rumley, Anne Kelly, Brussard, Cushman, Dichtl, Ferrara, Gordon D. Lowe, Gornstein, Herrington, Hokanson, Hulley, Ian A. Greer, John R. Petrie, Joyce McKenzie, Kanaya, Kenneth Paterson, Knopp, Koh, Kroon, Kroon, Lokkegaard, Lowe, Lowe, Lowe, Lynne Crawford, Manning, Meade, Naveed Sattar, Perera, Petitti, Pradhan, Rapp, Ridker, Ridker, Rossouw, Sattar, Sattar, Stephen Gallacher, Stork, Van Baal, Van Baal, Vehkavaara, Woodward, Zanger   +46 more
core   +1 more source