Results 1 to 10 of about 13,209 (106)
Heparin-stimulated inhibition of factor IXa generation and factor IXa neutralization in plasma [PDF]
Blood, 1990 Generation and inhibition of activated factor IXa was studied in factor XIa-activated plasma containing 4 mmol/L free calcium ions and 20 mumol/L phospholipid (25 mol% phosphatidylserine/75 mol% phosphatidylcholine). Interference of other (activated) clotting factors with the factor IXa activity measurements could be avoided by using a highly specific ...
Pieters, J., Lindhout, T., Willems, G.
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The Significance of Circulating Factor IXa in Blood [PDF]
Journal of Biological Chemistry, 2004 The presence of activation peptides (AP) of the vitamin K-dependent proteins in the phlebotomy blood of human subjects suggests that active serine proteases may circulate in blood as well. The goal of the current study was to evaluate the influence of trace amounts of key coagulation proteases on tissue factor-independent thrombin generation using ...
Kenneth G. Mann +4 more
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Factor IXa Inhibitors as Novel Anticoagulants [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Currently available anticoagulants are limited by modest therapeutic benefits, narrow clinical applications, increased bleeding risk, and drug-induced thrombophilia. Because factor IX plays a pivotal role in tissue factor (TF)–mediated thrombin generation, it may represent a promising target for drug development.
Kristian C.D. Becker +3 more
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Activation of factor X by factors IXa and VIII; a specific assay for factor IXa in the presence of thrombin-activated factor VIII [PDF]
Blood, 1978 Abstract We studied the activation of factor X by the intrinsic pathway of blood coagulation using a new assay of factor X activation. When factor X tritiated in its sialic acid residues is activated, activation can be measured by the release of tritiated activation peptide, and the initial rate of activation can be determined under ...
Mae B. Hultin, Yale Nemerson
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Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus) [PDF]
, 1995 From the saliva of the vampire bat Desmodus rotundus, we isolated an unknown anticoagulant protein which we have named draculin. Its molecular mass as determined by non-reduced SDS-PAGE is about 83 kDa.
Apitz-Castro, Rafael +5 more
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Activation of factor VIII by factor IXa [PDF]
Blood, 1982 Abstract Thrombin causes an increase in factor VIII coagulant (VIII:C) activity, which is followed by a decay of VIII:C activity to below baseline levels. It has been suggested that a similar interaction of trace amounts of thrombin and factor VIII is a necessary prerequisite before factor VIII can participate in the coagulation cascade.
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Activation of factor IX by factor XIa:A spectrophotometric assay for factor IX in human plasma [PDF]
, 1982 The activation of Factor IX by partially purified Factor XIa was followed by active site titration, gelelectrophoresis and by a spectrophotometric assay.
Hemker, H.C. +4 more
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Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules [PDF]
, 1990 We have recently shown that thrombin-stimulated human platelets have specific, saturable receptors for factor IXa, occupancy of which promotes factor X activation (Ahmad, S. S., Rawala-Sheikh, R., and Walsh, P. N. (1989) J. Biol. Chem.
AHMAD, S.
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Einstein's Equations in the Presence of Signature Change [PDF]
, 1996 We discuss Einstein's field equations in the presence of signature change using variational methods, obtaining a generalization of the Lanczos equation relating the distributional term in the stress tensor to the discontinuity of the extrinsic curvature.
Lanczos C., Tevian Dray
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Localization of Factor IXa and Factor VIIIa Interactive Sites [PDF]
Journal of Biological Chemistry, 1995 The contribution of the catalytic and noncatalytic domains of factor IXa to the interaction with its cofactor, factor VIIIa, was evaluated. Two proteolytic fragments of factor IXa, lacking some or all of the serine protease domain, failed to mimic the ability of factor IXa to enhance the reconstitution of factor VIIIa from isolated A1/A3-C1-C2 dimer ...
Leonid Medved +2 more
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