Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A. [PDF]
Blood, 2014 Muto A +14 more
europepmc +3 more sources
Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target. [PDF]
Pharmacol Res Perspect, 2016 The benefits of novel oral anticoagulants are hampered by bleeding. Since coagulation factor IX (fIX) lies upstream of fX in the coagulation cascade, and intermediate levels have been associated with reduced incidence of thrombotic events, we evaluated ...
Ankrom W +11 more
europepmc +4 more sources
The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D. [PDF]
J Biol Chem, 2013 Background: The heparin activation mechanism of antithrombin as a factor IXa and Xa inhibitor is not established. Results: Mutations adjacent to helix D result in full activation of antithrombin without heparin.
Dementiev A +6 more
europepmc +4 more sources
Biomolecules, 2023 The interaction between coagulation factors Xa and IXa and the activated state of their inhibitor, antithrombin (AT),have been investigated using X-ray diffraction studies. However, only mutagenesis data are available for non-activated AT. Our aim was to
Gábor Balogh, Zsuzsanna Bereczky
doaj +2 more sources
Factor VIIa and Factor IXa Inhibitors as Anticoagulants: A Review [PDF]
Indian Journal of Pharmaceutical Education and Research, 2017 Introduction: Anticoagulants are used as preventive agents in deep vein thrombosis to prevent blood clots, venous and arterial thromboembolism, but the current therapy of anticoagulants have several limitations like patient variable response, enhanced ...
Kumbhar Santosh Sahadeo +4 more
semanticscholar +3 more sources
Journal of Biological Chemistry, 1994 Factor VIIIa is inactivated by both factor IXa and activated protein C. The latter protease rapidly attacked a site at Arg562 (A2 subunit), whereas both proteases slowly cleaved factor VIIIa at Arg336 (A1 subunit). Cofactor inactivation catalyzed by activated protein C was 8-fold faster than that catalyzed by factor IXa. Simultaneous reaction of factor
Lisa M. Regan +4 more
openalex +3 more sources
Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential. [PDF]
Blood Adv, 2023 Key Points • K1813 in the FVIII A3 domain, considered to be an FXa-binding site, is responsible for the A2 subunit dissociation of FVIIIa.• The FVIII-K1813A mutant showed higher global coagulation potential vs WT because of reduced A2 dissociation and ...
Nakajima Y +4 more
europepmc +2 more sources
Factor IXa variants resistant to plasma inhibitors enhance clot formation in vivo.
Blood, 2023 Factor IXa plays a pivotal role in coagulation by contributing to the activation of factor X via the intrinsic pathway. While antithrombin and other plasma inhibitors are thought to regulate factor IXa procoagulant function, the impact of factor IXa ...
Ivanciu L, Arruda VR, Camire RM.
europepmc +2 more sources
Plasmin-mediated proteolysis of human factor IXa in the presence of calcium/phospholipid: Conversion of procoagulant factor IXa to a fibrinolytic enhancer. [PDF]
J Thromb Haemost, 2020 Factor (F) IX/IXa inactivation by plasmin has been studied; however, whether plasmin converts FIXa to a fibrinolytic enhancer is not known.
Schmidt AE +3 more
europepmc +2 more sources
Residues of the 39-loop restrict the plasma inhibitor specificity of factor IXa. [PDF]
J Biol Chem, 2013 Yang L, Rezaie AR.
europepmc +3 more sources