Results 11 to 20 of about 13,209 (106)

Potent Anticoagulant Aptamer Directed against Factor IXa Blocks Macromolecular Substrate Interaction [PDF]

, 2012
An aptamer targeting factor IXa has been evaluated in animal models and several clinical studies as a potential antithombotic therapy. We elucidate the molecular mechanism by which this aptamer acts as an anticoagulant.
Monroe, Dougald M., Sullenger, Bruce, Woodruff, Rebecca   +2 more
core   +2 more sources

Localization of the Heparin Binding Exosite of Factor IXa [PDF]

Journal of Biological Chemistry, 2002
Factor IXa (FIXa) is known to have a binding site for heparin that has not been mapped by a mutagenesis study. By homology modeling based on structural data, we identified eight basic residues in the catalytic domain of FIXa that can potentially bind to heparin.
Likui Yang, Alireza R. Rezaie, Chandrashekhara Manithody   +2 more
openaire   +3 more sources

Higgsing M2 to D2 with gravity: N=6 chiral supergravity from topologically gauged ABJM theory [PDF]

, 2010
We present the higgsing of three-dimensional N=6 superconformal ABJM type theories coupled to conformal supergravity, so called topologically gauged ABJM theory, thus providing a gravitational extension of previous work on the relation between N M2 and N
A Gustavsson, A Gustavsson, A Maloney, Bengt E. W. Nilsson, BEW Nilsson, BEW Nilsson, Constantinos Papageorgakis, D Grumiller, D Grumiller, E Bergshoeff, EA Bergshoeff, GR Dvali, H Liu, H Nastase, H Nastase, HJ Kim, Horatiu Nastase, J Bagger, J Bagger, J Bagger, J Bagger, J Distler, J Palmkvist, JA Harvey, JA Harvey, JH Horne, K Skenderis, L Randall, M Becker, M Raamsdonk Van, M Schnabl, MA Bandres, MJ Duff, N Lambert, N Lambert, O Aharony, PK Townsend, PK Townsend, S Deser, S Deser, S Deser, S Mukhi, S Terashima, T Li, U Gran, W Li, WD Goldberger, X Chu, Xiaoyong Chu, Y Kim, Y Pang   +50 more
core   +2 more sources

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

A 60-year time series analyses of the upwelling along the Portuguese Coast [PDF]

, 2019
Coastal upwelling has a significant local impact on marine coastal environment and on marine biology, namely fisheries. This study aims to evaluate climate and environmental changes in upwelling trends between 1950 and 2010.
Arístegui, Bettencourt, Borges, Fiúza, Fiúza, Francisco Leitão, Lavin, Maria Alexandra Teodósio, Moita, Patrícia Laginha Silva, Paulo Relvas, Rodionov, Rodionov, Vasco Vieira, Vânia Baptista, Wooster, Zuur   +16 more
core   +1 more source

Two-Loop Partition Function in the Planar Plane-Wave Matrix Model [PDF]

, 2004
We perform two independent calculations of the two-loop partition function for the large N 't Hooft limit of the plane-wave matrix model, conjectured to be dual to the decoupled little string theory of a single spherical type IIA NS5-brane.
Aharony, Anastasia Volovich, Beisert, Berenstein, Dasgupta, Dasgupta, Furuuchi, Kim, Kim, Kim, Klose, Maldacena, Marcus Spradlin, Mark Van Raamsdonk, Spradlin, Sundborg   +15 more
core   +2 more sources

Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa [PDF]

Blood, 1992
Abstract Factor IXa was shown to inactivate both factor VIII and factor VIIIa in a phospholipid-dependent reaction that could be blocked by an antifactor IX antibody. Factor IXa-catalyzed inactivation correlated with proteolytic cleavages within the A1 subunit of factor VIIIa and within the heavy chain (contiguous A1-A2-B domains) of ...
Philip J. Fay, Barry J. Lamphear
openaire   +4 more sources

The Role of Factor IXa and Factor VIII in the Activation of Factor X. [PDF]

Thrombosis and Haemostasis, 1977
Factor IXa and factor VIII participate in the middle phase of blood coagulation. These two proteins convert factor X to factor Xa in the presence of calcium ions and phospholipid. The coagulant activity of factor VIII is increased 50-100 fold by the addition of thrombin, and this activity is stabilized in the presence of CaCl2.
Earl W. Davie, Gordon A. Vehar, Kazuo Fujikawa, Richard G. Di Scipio   +3 more
openaire   +1 more source

Operation and control of a current source converter series tapping of an LCC-HVDC link for integration of offshore wind power plants [PDF]

, 2016
This work presents a series tapping station for integrating Offshore Wind Power Plants (OWPP) into a (Line Commutated Converter High Voltage Direct Current) LCC-HVDC transmission system.
Galceran Arellano, Samuel, Gomis Bellmunt, Oriol, Prieto Araujo, Eduardo, Sau Bassols, Joan   +3 more
core   +2 more sources

Inhibition of human factor IXa by human antithrombin

Journal of Biological Chemistry, 1975
A procedure is presented for the purification of Factor IX from human plasma. The final product is homogeneous as judged by disc gel electrophoresis and sodium dodecyl sulfate gel electrophoresis. Furthermore, it is completely free of other coagulation component activities.
PW McKenna, RD Rosenberg, JS Rosenberg
openaire   +3 more sources