The role of emicizumab, a bispecific factor IXa- and factor X-directed antibody, for the prevention of bleeding episodes in patients with hemophilia A. [PDF]
Ther Adv Hematol, 2018 Hemophilia A, characterized by impaired or absent expression of factor VIII, has long been managed via direct factor replacement. Functionally, factor VIII acts as a cofactor for factor IXa and allows activation of factor X, which, in combination with ...
Knight T, Callaghan MU.
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Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Plautz WE +9 more
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An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa. [PDF]
Proc Natl Acad Sci U S ASignificance Blood clotting is a balanced process that ensures rapid control of bleeding without causing thrombosis. Factor IXa, a protease in the blood coagulation pathway, exemplifies this requirement for balance.
Kolyadko VN +4 more
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Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. [PDF]
J Biol Chem, 2012 Sullenger B, Woodruff R, Monroe DM.
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Factor Xa; thrombin (factor IIa; F2); factor IXa; factor VIIa/tissue factor complex [PDF]
Science-Business eXchange, 2014 openalex +3 more sources
Elevated Plasma Factor IXa Activity in Premenopausal Women on Hormonal Contraception. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Tanratana P +4 more
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Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study. [PDF]
J Thromb Haemost, 2019 Essentials Consensus sequence and biochemical data suggest a Na+‐site in the factor (F) IXa protease domain. X‐ray structure of the FIXa EGF2/protease domain at 1.37 Å reveals a Na+‐site not observed earlier.
Vadivel K +5 more
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Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa. [PDF]
J Biol Chem, 2009 Jagannathan I +3 more
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Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors
Bioorganic & Medicinal Chemistry Letters, 2017 Isao Sakurada +21 more
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