Results 71 to 80 of about 12,711,395 (233)

Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa [PDF]

Blood, 1992
Abstract Factor IXa was shown to inactivate both factor VIII and factor VIIIa in a phospholipid-dependent reaction that could be blocked by an antifactor IX antibody. Factor IXa-catalyzed inactivation correlated with proteolytic cleavages within the A1 subunit of factor VIIIa and within the heavy chain (contiguous A1-A2-B domains) of ...
B J, Lamphear, P J, Fay
openaire   +3 more sources

Determinantal Calabi-Yau varieties in Grassmannians and the Givental $I$-functions

, 2018
We examine a class of Calabi-Yau varieties of the determinantal type in Grassmannians and clarify what kind of examples can be constructed explicitly.
Honma, Yoshinori, Manabe, Masahide
core   +1 more source

Frequency-domain gravitational waves from non-precessing black-hole binaries. II. A phenomenological model for the advanced detector era [PDF]

, 2015
We present a new frequency-domain phenomenological model of the gravitational-wave signal from the inspiral, merger and ringdown of non-precessing (aligned-spin) black-hole binaries.
Bohé, Alejandro, Forteza, Xisco Jiménez, Hannam, Mark, Husa, Sascha, Khan, Sebastian, Ohme, Frank, Pürrer, Michael   +6 more
core   +2 more sources

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil, Wilhelm Huisinga, Jane Knöchel   +2 more
wiley   +1 more source

Effective Lagrangian and Topological Interactions in Supersolids

, 2005
We construct a low-energy effective Lagrangian describing zero-temperature supersolids. Galilean invariance imposes strict constraints on the form of the effective Lagrangian.
A. F. Andreev, D. T. Son, H. Leutwyler
core   +1 more source

Human Protein Z as the Second Known Heme‐Binding Protein from the Endogenous Blood Coagulation Inhibitor System

ChemBioChem, Volume 27, Issue 1, January 2026.
Protein Z is a vitamin K‐dependent anticoagulant with elusive molecular functions. Herein, it is shown that heme binds to protein Z and induces conformational changes. One histidine‐based heme‐binding motif is identified. High heme‐binding affinity and functional effects are demonstrated on protein level. These findings shed new light on the structural
Paula Lindemann, Marie‐T. Hopp
wiley   +1 more source

Black hole uniqueness theorems and new thermodynamic identities in eleven dimensional supergravity

, 2012
We consider stationary, non-extremal black holes in 11-dimensional supergravity having isometry group $\mathbb{R} \times U(1)^8$. We prove that such a black hole is uniquely specified by its angular momenta, its electric charges associated with the ...
Bossard G, Bunting G L, Camps J Emparan R, Carter B, Chruściel P T Costa J L, Coley A, Elvang H, Emparan R, Emparan R, Freudenthal H, Gauntlett J P, Gauntlett J P, Gauntlett J P, Godazgar M, Helgason S, Heusler M, Julia B, Kastor D, Kunduri H K, Masood-ul-Alam A K M, Mazur P O, Moncrief V, Orlik P, Pomeransky A A Sen’kov R A, Pravdova A, Stefan Hollands, Wald R M, Wald R M, Wald R M   +28 more
core   +1 more source

Massive Intra‐Abdominal Pseudotumor in a Patient With Hemophilia A Treated With Emicizumab: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Hemophilic pseudotumors, a rare complication of bleeding disorders, are more common in settings with limited access to clotting factor concentrates. Subcutaneous emicizumab, a relatively novel therapy for hemophilia A, was investigated for its ability to stabilize an inoperable pseudotumor in a patient with factor VIII deficiency in an under ...
C. J. Kilach, C. Njuguna, F. Njuguna, C. M. Wanjiku, K. F. Molitor, I. A. Janson, S. M. Mbunya, A. D. Shapiro, J. Sagar, A. Greist   +9 more
wiley   +1 more source

Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro

TH Open, 2018
Emicizumab is a humanized bispecific antibody that binds simultaneously to factor (F) IXa and FX replacing the cofactor function of FVIIIa. Because emicizumab recognizes FIX/FIXa and FX/FXa, a question may arise whether emicizumab competes with ...
Mariko Noguchi-Sasaki, Tetsuhiro Soeda, Atsunori Ueyama, Atsushi Muto, Michinori Hirata, Hidetomo Kitamura, Kaori Fujimoto-Ouchi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, Takehisa Kitazawa   +10 more
doaj   +1 more source

Three-Dimensional Integrable Models and Associated Tangle Invariants [PDF]

, 1994
In this paper we show that the Boltzmann weights of the three-dimensional Baxter-Bazhanov model give representations of the braid group, if some suitable spectral limits are taken.
A. B. Zamolodchikov, A. B. Zamolodchikov, B. L. Cerchiai, D. Goldschmidt, D. N. Yetter, E. Date, E. Date, F. Valz-Gris, M. Martellini, M. T. Jaekel, M. Wadati, P. J. Fryed, R. J. Baxter, R. M. Kashaev, R. M. Kashaev, R. M. Kashaev, T. Deguchi, T. Kobayashi, V. R. Jones, V. V. Bazhanov, V. V. Bazhanov, V. V. Bazhanov, V. V. Bazhanov   +22 more
core   +3 more sources