Results 51 to 60 of about 3,481,430 (306)

Antitumor Activity and Safety of Trastuzumab Deruxtecan in Patients With HER2-Low–Expressing Advanced Breast Cancer: Results From a Phase Ib Study

Journal of Clinical Oncology, 2020
PURPOSE Trastuzumab deruxtecan (T-DXd, formerly DS-8201a) is a novel human epidermal growth factor receptor 2 (HER2)-targeted antibody drug conjugate (ADC) with a topoisomerase I inhibitor payload.
S. Modi, Haeseong Park, R. Murthy, H. Iwata, K. Tamura, J. Tsurutani, A. Moreno-Aspitia, T. Doi, Y. Sagara, C. Redfern, I. Krop, Caleb Lee, Y. Fujisaki, M. Sugihara, Lin Zhang, J. Shahidi, S. Takahashi   +16 more
semanticscholar   +1 more source

Analyzing display photometric features through time-dependent dynamics of accommodative responses and ocular imaging quality

Scientific Reports
To optimize screen quality for a better and healthier visual experience, it is essential to understand how photometric parameters impact ocular physiological parameters. However, the relationship between these photometric and physiological parameters has
Jianqi Cai, Shanshan Zeng, Ya Guo, Wentao Hao   +3 more
doaj   +1 more source

TMT-based quantitative proteomic analysis reveals eggshell matrix protein changes correlated with eggshell quality in Jing Tint 6 laying hens of different ages

Poultry Science
: The decline in eggshell quality resulting from aging hens poses a threat to the financial benefits of the egg industry. The deterioration of eggshell quality with age can be attributed to changes in its ultrastructure and chemical composition. Specific
Dan-rong Zhao, Li-bing Gao, Fei Gong, Jia Feng, Hai-jun Zhang, Shu-geng Wu, Jing Wang, Yu-na Min   +7 more
doaj   +1 more source

Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A.

New England Journal of Medicine, 2021
BACKGROUND The goal of gene therapy for patients with hemophilia A is to safely impart long-term stable factor VIII expression that predictably ameliorates bleeding with the use of the lowest possible vector dose.
Lindsey A. George, P. Monahan, M. Eyster, S. Sullivan, M. Ragni, S. Croteau, J. Rasko, M. Recht, Benjamin J. Samelson-Jones, A. Macdougall, Kristen Jaworski, R. Noble, M. Curran, K. Kuranda, F. Mingozzi, Tiffany Chang, K. Reape, X. Anguela, K. High   +18 more
semanticscholar   +1 more source

Science Is Indispensable to Frugal Innovations

Technology Innovation Management Review, 2018
In recent years, frugal innovations have become widely popular due to their no-frills nature that entails lower costs. However, most of the frugal innovations, at least at the grassroots level, are makeshift contraptions, made from indigenous ingenuity ...
Balkrishna C. Rao
doaj   +1 more source

Safety of Recombinant Factor VIIa [PDF]

Transfusion Alternatives in Transfusion Medicine, 2003
SUMMARYRecombinant activated factor VII is an activator of blood coagulation that is highly effective as a hemostatic agent in patients with complicated hemophilia and other clotting disorders who experience major bleeding or need to undergo surgery.
openaire   +1 more source

Stability Assessment of the Dam of a Tailings Pond Using Computer Modeling—Case Study: Coroiești, Romania

Applied Sciences, 2023
Anthropogenic activities related to mining generate both progress and a vast amount of waste that is responsible for environmental degradation. The Jiu Valley is one of the areas of Romania where mining has affected large areas of land, used to build ...
Florin Dumitru Popescu, Sorin Mihai Radu, Andrei Andras, Ildiko Brinas, Mihaela-Olga Marita, Mirela Ancuta Radu, Constantin Laurentiu Brinas   +6 more
doaj   +1 more source

Development of predicting model for safety behaviour based on safety psychology and working environment [PDF]

, 2018
The increasing trend of occupational accident due to unsafe act and unsafe condition especially in construction site suggests the need for more proactive safety assessment model.
Md Asari, Mohammad Khairul Shaleh
core  

Relationships between mental health and styles of help-seeking among care workers in comparison with the general population

Discover Mental Health
Background Care workers in long-term nursing homes often experience burdens and a high rate of resignations. This study aimed to investigate the mental health of care workers and to examine the relationship between the tendency to seek help and their ...
Tomoko Matsui, Hikaru Oba, Ryosuke Uchida, Tsukasa Teraguchi   +3 more
doaj   +1 more source

Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors

Journal of Intensive Care, 2018
BackgroundAlthough factor Xa inhibitors have become a popular choice for chronic oral anticoagulation, effective drug reversal remains difficult due to a lack of specific antidote.
J. Tao, E. Bukanova, S. Akhtar
semanticscholar   +1 more source