Results 61 to 70 of about 1,074,831 (266)
Impact of Rain Water Infiltration on the Stability of Earth Slopes [PDF]
International Journal of Economic and Environment Geology, 2016 Slope failure occurs very often in natural and man-made slopes which are subjected to frequent changes in ground water level, rapid drawdown, rainfall and earthquakes.
Muhammad Farooq Ahmed +2 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Applied SciencesThe shear strength of unsaturated soils exhibits significant nonlinearity, while previous studies often simplified it with linear strength models. The objective of this paper is to investigate the distinctions in the stability of three-dimensional (3D ...
Yushan Yang, Hong Liao, Jianqun Zhu
doaj +1 more source
Applied Sciences, 2019 The paper presents the results of research on the influence of compaction on the shear strength of fly ash, unburnt and burnt coal wastes, and a composite (a mixture of unburnt coal waste and 30% of fly ash).
Andrzej Gruchot, Tymoteusz Zydroń
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Identifying NPP operator stressors using grounded theory
Scientific ReportsNuclear power plant (NPP) operators manage crucial decision-making and operational tasks in precarious and complex environments, where psychological stress directly correlates with system safety and operational efficiency.
Ye Wang +4 more
doaj +1 more source
Cardiac Factors of Safety [PDF]
Circulation Research, 1953 R S, ALEXANDER, C J, WIGGERS
openaire +2 more sources