Results 261 to 270 of about 7,574,249 (329)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

An Examination of the Factor Structure of the Jefferson Scale for Physician Empathy (JSPE) in Indian Clinicians. [PDF]

Indian J Psychol Med
Chichra A, Abhijnhan A, Tharyan P.
europepmc   +1 more source

Structure and function analysis of PriC, a replication restart primosomal factor in Escherichia coli

, 2014
Takahiko Aramaki
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Psychometric properties and factor structure of the Persian version of worry questionnaire - Contrast avoidance model. [PDF]

J Educ Health Promot
Javaherirenani R, Ahadianfard P, Ashouri A.   +2 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The child and adolescent trauma screen self- and caregiver-report: Factor structure, measurement invariance, and concurrent validity in a clinical sample of children and adolescents. [PDF]

Psychol Trauma
Kemp EC, Thakur H, Espeleta HC, Ridings LE, Hanson RF, Ruggiero K, Davidson TM.   +6 more
europepmc   +1 more source

Changes in microbial community structure and responses to environmental factors in heavily polluted rivers remediated by bio-wax

Lei Dong, Li Lin, Quanxi Xu, Liangyuan Zhao, Xingrui Qi, Guochuan Yin, Xiong Pan, Aihua Xu, Yujie Liu   +8 more
openalex   +1 more source