Results 111 to 120 of about 2,341,716 (244)

Fator V de Leiden Factor V Leiden

Revista Brasileira de Hematologia e Hemoterapia, 2005
José M. P. Godoy
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reply to "Important Methodological and Statistical Concerns Regarding the Association of Factor V Leiden and MTHFR Polymorphisms With COVID-19 Outcomes". [PDF]

Immun Inflamm Dis
Çıralıoğlu H, Adalı Y, Özen M, Oskay A, Yılmaz A, Seyit M, Köseler A, Türkçüer İ.   +7 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Obese Adolescent with Factor V Leiden-Related Pulmonary Embolism: Case-Based Insight into Paediatric Thrombosis Management. [PDF]

Diagnostics (Basel)
Bossowski F, Bossowska M, Masłowska K, Śliwko P, Żórawska H, Semeran K, Janica JR, Bossowski A.   +7 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Genetic and Clinical Characteristics of Russian Patients with Congenital Factor V Deficiency. [PDF]

Int J Mol Sci
Pshenichnikova O, Poznyakova J, Shchemeleva E, Surin V, Yakovleva E, Likhacheva E, Dimitrieva O, Yastrubinetskaya O, Andreev N, Sats N, Zozulya N.   +10 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

DIEP reconstruction in a patient with Factor V Leiden deficiency: A case report and literature review. [PDF]

JPRAS Open
Quinn O, Bhatti S, Rosich-Medina A.
europepmc   +1 more source