Results 1 to 10 of about 130,862 (286)
PURIFICATION AND CHARACTERIZATION OF A VARIANT OF HUMAN PROTHROMBIN: PROTHROMBIN SEGOVIA [PDF]
Thrombosis Research, 1997 A dysprothrombin designated prothrombin Segovia was isolated from the plasma of an individual with normal prothrombin antigen and prothrombin activity lesser than 25% of the control prothrombin activity. Activation by prothrombinase complex showed a lower amidolytic than clotting activity, which suggests a lesser generation of active intermediates than
Montaño, L.F. (Luis F.) +6 more
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Cancer Medicine, 2021 The previous retrospective study suggested that dosing vitamin K may enhance the anticancer action of sorafenib against hepatocellular carcinoma. To confirm it, we performed a phase II, randomized, open‐label study. Patients with hepatocellular carcinoma
Yoshimichi Haruna +2 more
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Factor V G1691A (Leiden) is a major etiological factor in Egyptian Budd-Chiari syndrome patients
Turkish Journal of Hematology, 2011 OBJECTIVE: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins). The aim of this study was to determine the prevalence
Tawhida Y. Abdel Ghaffar +7 more
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Research and Practice in Thrombosis and Haemostasis, 2019 Background Portal vein thrombosis (PVT) is common in cirrhosis. PVT is associated with high morbidity and mortality. Individual reports suggest that PVT occurs more frequently in patients with cirrhosis and inherited thrombophilia.
Steven D. Ma +5 more
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International Journal of Preventive Medicine, 2018 Background: Maternal thrombophilia has been identified as a risk factor for recurrent pregnancy loss (RPL). The aim of this study was to investigate the association between prothrombin G20210A and factor V Leiden (FVL) polymorphisms in women with RPL and
Mohammad Taghi Kardi +3 more
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Induction of prothrombin synthesis by prothrombin fragments. [PDF]
Proceedings of the National Academy of Sciences, 1981 The mechanisms by which blood levels of prothrombin (PT) are regulated in the vitamin K-sufficient state are unknown. We have studied PT synthesis by Reuber H-35 rat hepatoma cells exposed to vitamin K and [3H]leucine in serum-free cultures. Administration to the culture system of exogenous bovine PT and rat PT was characterized by increases in ...
C B, Graves +4 more
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PathophysiologyBackground: Thrombophilia, a predisposition to develop blood clots, is very common and can have serious sequelae. Aim: This study aimed to determine the prevalence of three thrombophilia-related genetic variants—factor V Leiden (FVL), prothrombin (F2 ...
Sapha Shibeeb +5 more
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Animals, 2022 The Asian elephant population is continuously declining due to several extrinsic reasons in their range countries, but also due to diseases in captive populations worldwide.
Sónia A. Jesus +8 more
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Role of Thrombin in Central Nervous System Injury and Disease
Biomolecules, 2021 Thrombin is a Na+-activated allosteric serine protease of the chymotrypsin family involved in coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin in the brain has been explored. Low concentrations of thrombin are
Nathan A. Shlobin +4 more
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The Conversion of Bovine Abnormal Prothrombin into Prothrombin [PDF]
Thrombosis and Haemostasis, 1977 In order to characterize the enzyme system which converts abnormal prothrombin (PIVKA-II) in prothrombin we prepared liver cell-free extracts from normal healthy cows. The enzyme system devoid of either precursor or prothrombin was isolated by differential centrifugation and partly purified with the aid of column chromatography.The carboxylation of ...
C. Vermeer, B.A. M. Soute, H.C. Hemker
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