Results 1 to 10 of about 190,185 (400)

MASP-1 of the complement system promotes clotting via prothrombin activation. [PDF]

Molecular Immunology, 2015
Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity, and it has been shown to activate coagulation factors.
Gál, Péter, Lorenz Jenny, Dobó, József, József Dobó, Verena Schroeder, Schroeder, Verena, Jenny, Lorenz, Péter Gál   +7 more
core   +2 more sources

Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of Activation [PDF]

Journal of Biological Chemistry, 2013
Background: The x-ray structure and mechanism of activation of prothrombin remain elusive. Results: X-ray and solution studies document conformation flexibility of prothrombin.
Nicola Pozzi, Zhiwei Chen, David W. Gohara, Weiling Niu, Tomasz Heyduk, Enrico Di   +5 more
openalex   +2 more sources

Prothrombin synthesis in the dog

American Journal of Physiology, 1964
Liver parenchymal cells were found to be the sites for production of prothrombin. Dogs were employed and their rate of prothrombin synthesis was modified as desired by giving either Coumadin or vitamin K1.
Marion I Barnhart, M I Barnhart
exaly   +2 more sources

Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate [PDF]

Circulation, 2011
Elise S. Eerenberg, Pieter W. Kamphuisen, Meertien K. Sijpkens, Joost C.M. Meijers, Harry R. Büller, Marcel Levi   +5 more
openalex   +2 more sources

Prothrombin Activity and Concentration in Healthy Subjects with and without the Prothrombin G20210A Mutation

Thrombosis Research, 2000
A common mutation in the prothrombin gene (G20210A) is associated with elevated prothrombin levels and thrombosis. The pathomechanism related to the G20210A mutation is currently not understood and the interdependence of prothrombin activity and ...
Nicolas Von Ahsen, P Lewczuk, Ekkehard Schutz   +2 more
exaly   +2 more sources

Elevated Prothrombin Promotes Venous, but Not Arterial, Thrombosis in Mice

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Objective—Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis.
Maria M Aleman, James R Byrnes, Kellie R Machlus   +2 more
exaly   +2 more sources

Congenital prothrombin deficiency: an update

Seminars in Thrombosis and Hemostasis, 2013
Prothrombin (factor II [FII]) deficiency is a rare inherited coagulation disorder, having a prevalence of approximately 1 in 2,000,000. Two phenotypes can be distinguished: (1) true hypoprothrombinemia (type I deficiency), characterized by ...
De Cristofaro, Raimondo, Lancellotti, Stefano, Basso, Maria   +2 more
core   +2 more sources

Prothrombin A19911G polymorphism and the risk of venous thromboembolism

Journal of Thrombosis and Haemostasis, 2006
Background: The A &rt; G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established.
Ida Martinelli, Alberto Tosetto, Cristina Legnani   +2 more
exaly   +2 more sources

Cryo-EM structure of the prothrombin-prothrombinase complex

Blood, 2022
In this Plenary Paper, Ruben et al determine structures of the prothrombinase complex that are responsible for the proteolytic conversion of prothrombin to thrombin, the penultimate step in the coagulation cascade.
E. Ruben, B. Summers, M. Rau, James Fitzpatrick, E. Di Cera   +4 more
semanticscholar   +1 more source

Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation [PDF]

Blood, 2012
Matthew F. Whelihan, Vicentios Zachary, Thomas Orfeo, Kenneth G. Mann   +3 more
openalex   +2 more sources