Results 1 to 10 of about 2,341,716 (244)

First report of bilateral avascular necrosis (AVN) of the femoral heads in a patient with dual factor V deficiency and factor V Leiden mutation: A unique coagulopathy intersection with therapeutic insights [PDF]

Clinical Medicine
We present what appears to be the first documented case worldwide of bilateral avascular necrosis (AVN) of the femoral heads in a young adult with the rare co-occurrence of congenital factor V (FV) deficiency and heterozygous FV Leiden mutation.
Wei Li, Huibo Li, Xixi Dou, Deqiang Zheng, Chengyao Liu   +4 more
doaj   +2 more sources

Effect of a truncated mutant factor V on hemostatic function and embryonic development in mice [PDF]

Scientific Reports
Factor V is an essential protein in the blood clotting process and plays a central role in secondary hemostasis. Its deficiency causes a rare inherited disorder characterized by episodes of severe bleeding, some of which can be life-threatening. Although
Andrea Miguel-Batuecas, Juan A. De Pablo-Moreno, Néstor Porras, Pablo Bermejo-Álvarez, Leopoldo González-Brusi, Luis J. Serrano, Javier M. De Pablo-Moreno, María José Sánchez, Mariano García-Arranz, Antonio Rodríguez-Bertos, Bilgimol Chumappumkal Joseph, Luis Revuelta, Antonio Liras   +12 more
doaj   +2 more sources

Activity of Labile Coagulation Factors, Factor X and Fibrinogen Level in Frozen Plasma versus Fresh Frozen Plasma [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Fresh Frozen Plasma (FFP) is a blood component separated from whole blood and frozen below -30°C within 8 hours of donation for optimum preservation of coagulation factors. However, logistic and geographical reasons may hamper separation of
Swarupa Nikhil Bhagwat, Jayashree Harihara Sharma, Omkar Ramakant Kadhane, Poonam Lalla   +3 more
doaj   +1 more source

Association of prothrombin, FV Leiden and MTHFR gene polymorphisms in the Montenegrin patients with venous thromboembolism [PDF]

Vojnosanitetski Pregled, 2021
Background/Aim. Polymorphisms of the factor V Leiden (FV G1691A), prothrombin (FII G20210A), and methylene-tetrahydrofolate reductase (MTHFR C677T) genes are the most commonly investigated inherited risk factors for developing venous thromboembolism (VTE)
Teofilov Slađana, Magić Zvonko, Miljanović Olivera, Ostojić Tatjana, Bulatović Milena   +4 more
doaj   +1 more source

Novel single nucleotide mutations in exon-10 of human coagulation Factor V gene in patients with pulmonary thromboembolism [PDF]

Journal of Cardiovascular and Thoracic Research, 2020
Introduction: Acute pulmonary thromboembolism (PTE) presents with wide spectrum and has variable prognosis. Factor V Leiden (FVL) is the most common inherited thrombophilia, with a prevalence of 3%-7% in the general US population, approximately 5% in ...
Latheef Kasala, Rajasekhar Durgaprasad, Vanajakshamma Velam   +2 more
doaj   +1 more source

Association of Factor II G20210A, Factor V G1691A and methylenetetrahydrofolate reductase C677T gene polymorphism with different forms of myocardial infarction: ST segment elevation and non-ST segment elevation [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Coagulation Factor II G20210A and Factor V G1691A variants are moderately associated with coronary artery disease. Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene C677T is associated with myocardial infarction (MI) in ...
Ćućuz-Jokić Milica, Ilić Vesna, Cikota-Aleksić Bojana, Obradović Slobodan, Magić Zvonko   +4 more
doaj   +1 more source

Analysis of f5 gene polymorphism in men with coronary atherosclerosis using whole exome sequencing

Атеросклероз, 2021
Factor V, encoded by the F5 gene, is a procoagulant blood clotting factor that increases the production of thrombin, the central enzyme that converts fibrinogen to fibrin, which leads to the formation of a blood clot.
E. V. Striukova, E. V. Shakhtshneider, D. E. Ivanoshchuk, Yu. I. Ragino, Ya. V. Polonskaya, I. S. Murashov, A. M. Volkov, A. V. Kurguzov, A. M. Chernyavsky, E. S. Valeev, V. N. Maksimov, E. V. Kashtanova   +11 more
doaj   +1 more source

Posterior Fossa Hematoma Following Minor Trauma in an Infant with Rare Combined Factor V and Factor X Deficiency

Journal of Pediatric Neurosciences, 2021
Congenital combined deficiency of factor V and factor X deficiency is extremely rare. We report this for the first time in literature in an infant who developed acute subdural hematoma in posterior fossa leading to hydrocephalus.
Indrajit Rana, Laxmi Narayan Tripathy
doaj   +1 more source

A Case of Acquired Factor V Deficiency in Patient with Bleeding

TH Open, 2020
Low frequency of rare diseases origins from missed diagnosis addressing to poor prognosis. Acquired factor V inhibitor is a very low frequent bleeding condition (prevalence: 0.09/100,000,000–0.29/1,000,000 per year).
Davide Vetri, Giovanni Lumera, Salvatore Tarascio, Salvatore Scuto, Elisa Marino, Giuliana Barcellona, Salvatore Santo Signorelli   +6 more
doaj   +1 more source

Case Report: Novel Mutation of F5 With Maternal Uniparental Disomy Causes Severe Congenital Factor V Deficiency

Frontiers in Pediatrics, 2022
We summarized two cases of congenital factor V deficiency (FVD) associated with a novel F5 mutation, and analyzed the relationship of the clinical features and genetic characteristics in congenital FVD.
Lin Cheng, Ying Li, Wenjuan Zhou, Tao Bo
doaj   +1 more source