Results 11 to 20 of about 2,320,405 (244)

Case Report: Novel Mutation of F5 With Maternal Uniparental Disomy Causes Severe Congenital Factor V Deficiency

open access: yesFrontiers in Pediatrics, 2022
We summarized two cases of congenital factor V deficiency (FVD) associated with a novel F5 mutation, and analyzed the relationship of the clinical features and genetic characteristics in congenital FVD.
Lin Cheng, Ying Li, Wenjuan Zhou, Tao Bo
doaj   +1 more source

Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer

open access: yesOncoImmunology, 2020
Background Factor (F) V is an essential cofactor in blood coagulation, however, F5 expression in breast tumors has also been linked to tumor aggressiveness and overall survival. The specific role of FV in breast cancer is yet unknown.
Mari Tinholt   +8 more
doaj   +1 more source

A Novel Phenotype of the Factor 5 Gene Mutation (Homozygote Met1736Val and Heterozygote Asp68His) Is Associated With Moderate Factor V Deficiency

open access: yesFrontiers in Medicine, 2022
BackgroundFactor V (FV) deficiency is a rare disease, with a low incidence rate in Asia. Therefore, the F5 mutation in the Taiwanese population is poorly understood.MethodsA Chinese family with FV deficiency was included, and the patient and his family ...
Yueh-Shih Chang   +8 more
doaj   +1 more source

Comparison between thrombophilic gene polymorphisms among high risk patients

open access: yesRomanian Journal of Internal Medicine, 2020
Introduction. The purpose of this study was to compare the role of the thrombophilic variants among two groups of high risk patients with vascular disorders and recurrent pregnancy loss.
Levkova Mariya   +4 more
doaj   +1 more source

Relationship between Coagulation Factors and Polymorphism of Effective Thrombophilic Genes with Recurrent Abortions

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Gene mutations leading to thrombophilic disorders and changes in blood coagulation factors during pregnancy play an important role in the occurrence of recurrent abortions.
Masoomeh Rezanezhadi   +1 more
doaj  

Diagnostic Accuracy of Different Methods in Detecting Factor V Leiden Mutation in Tertiary Care Centre

open access: yesPakistan Armed Forces Medical Journal, 2022
Objective: To determine the diagnostic accuracy of clotting based APCR assay in determining Factor V Leiden mutation with PCR as gold standard and to establish the frequency of factor V Leiden mutation in patients presenting with thrombophilia as well ...
Sidra Barlas   +5 more
doaj   +1 more source

Lipase and factor V (but not viral load) are prognostic factors for the evolution of severe yellow fever cases

open access: yesMemorias do Instituto Oswaldo Cruz, 2019
BACKGROUND Despite a highly efficacious vaccine, yellow fever (YF) is still a major threat in developing countries and a cause of outbreaks. In 2018, the Brazilian state of São Paulo witnessed a new YF outbreak in areas where the virus has not been ...
Luciana Vilas Boas Casadio   +11 more
doaj   +1 more source

The Factor V Activation Paradox [PDF]

open access: yesJournal of Biological Chemistry, 2004
The prothrombinase complex consists of the protease factor Xa, Ca2+, and factor Va assembled on an anionic membrane. Factor Va functions both as a receptor for factor Xa and a positive effector of factor Xa catalytic efficiency and thus is key to efficient conversion of prothrombin to thrombin.
Thomas, Orfeo   +5 more
openaire   +2 more sources

Multiple Coagulation Factor Deficiency: A Series of Eight Cases [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Multiple Coagulation Factor Deficiency (MCFD) is an uncommon haematological disorder characterised by simultaneous deficiency of multiple clotting factors, which leads to an increased risk of bleeding and compromised haemostasis. The present series aimed
Abhijith Lakshman   +2 more
doaj   +1 more source

Factores asociados a la violencia de género en mujeres del Centro Poblado de La Esperanza, Huánuco

open access: yesRevista Peruana de Ciencias de la Salud, 2019
Objective. To describe the factors that are associated with gender-based violence. Methods. An observational, transversal, prospective and correlational research was carried out on a sample of 333  women from the esperanza populated centre, amarilis ...
Amalia Leiva Yaro
doaj   +1 more source

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