Results 31 to 40 of about 123,279 (307)
OPTIMIZATION OF THE EVALUATION METHOD OF THE PERFORMANCE OF THERAPY USING INDIRECT ACTION ANTICOAGULANTS [PDF]
Biotechnologia Acta, 2022 Aim. Treatment by indirect anticoagulants (vitamin K antagonists) requires a personalized approach for controlling the overall level of prothrombin and the accumulation of its decarboxylated forms.
D. S. Korolova +6 more
doaj +1 more source
Autocatalysis in prothrombin activation [PDF]
, 1962 Two enzymes, thrombin and autoprothrombin C, are derived from purified prothrombin by autocatalytic activation in 25% sodium citrate solution.
Walter H. Seegers +2 more
core +1 more source
Arquivos Brasileiros de Cardiologia, 2007 FUNDAMENTO: O uso de anticoagulantes orais (ACO) é comum na prática cardiológica, tendo como principais indicações a fibrilação atrial e próteses valvares. Os pacientes em uso de ACO necessitam de controle freqüente do tempo de protrombina (TP).
Tiago Luiz Luz Leiria +3 more
doaj +1 more source
Cancer Medicine, 2021 The previous retrospective study suggested that dosing vitamin K may enhance the anticancer action of sorafenib against hepatocellular carcinoma. To confirm it, we performed a phase II, randomized, open‐label study. Patients with hepatocellular carcinoma
Yoshimichi Haruna +2 more
doaj +1 more source
Factor V G1691A (Leiden) is a major etiological factor in Egyptian Budd-Chiari syndrome patients
Turkish Journal of Hematology, 2011 OBJECTIVE: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins). The aim of this study was to determine the prevalence
Tawhida Y. Abdel Ghaffar +7 more
doaj +3 more sources
Research and Practice in Thrombosis and Haemostasis, 2019 Background Portal vein thrombosis (PVT) is common in cirrhosis. PVT is associated with high morbidity and mortality. Individual reports suggest that PVT occurs more frequently in patients with cirrhosis and inherited thrombophilia.
Steven D. Ma +5 more
doaj +1 more source
International Journal of Preventive Medicine, 2018 Background: Maternal thrombophilia has been identified as a risk factor for recurrent pregnancy loss (RPL). The aim of this study was to investigate the association between prothrombin G20210A and factor V Leiden (FVL) polymorphisms in women with RPL and
Mohammad Taghi Kardi +3 more
doaj +1 more source
MASP-1 of the complement system promotes clotting via prothrombin activation. [PDF]
, 2015 Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity, and it has been shown to activate coagulation factors.
Gál, Péter +7 more
core +1 more source
MASP-1 Induced Clotting--The First Model of Prothrombin Activation by MASP-1. [PDF]
, 2015 Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity.
Gál, Péter +7 more
core +1 more source
FXa mediated prothrombin cleavage. [PDF]
, 2015 Prothrombin activation by FXa. FXa cleaves prothrombin either at R271 or at R320. Intermediates gain their activity by cleavage at R320 and are then able to perform further cleavages at R155, R284, R383 and R393.
Verena Schroeder (325642) +3 more
core +1 more source