Results 51 to 60 of about 190,185 (400)

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

PLoS ONE, 2017
Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event.
R. Kremers, Marie-Claire F. Kleinegris, M. Ninivaggi, B. de Laat, H. ten Cate, G. Koek, R. Wagenvoord, H. Hemker   +7 more
semanticscholar   +1 more source

Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta‐analysis

Research and Practice in Thrombosis and Haemostasis, 2019
Background Portal vein thrombosis (PVT) is common in cirrhosis. PVT is associated with high morbidity and mortality. Individual reports suggest that PVT occurs more frequently in patients with cirrhosis and inherited thrombophilia.
Steven D. Ma, Jennifer Wang, Dmitri Bezinover, Zakiyah Kadry, Patrick G. Northup, Jonathan G. Stine   +5 more
doaj   +1 more source

Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting

Anesthesia and Analgesia, 2016
Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII.
K. Ghadimi, J. Levy, I. Welsby
semanticscholar   +1 more source

Association of Factor V Leiden and Prothrombin G20210A Polymorphisms in Women with Recurrent Pregnancy Loss in Isfahan Province, Iran

International Journal of Preventive Medicine, 2018
Background: Maternal thrombophilia has been identified as a risk factor for recurrent pregnancy loss (RPL). The aim of this study was to investigate the association between prothrombin G20210A and factor V Leiden (FVL) polymorphisms in women with RPL and
Mohammad Taghi Kardi, Elham Yousefian, Azra Allahveisi, Sanaz Alaee   +3 more
doaj   +1 more source

MASP-1 Induced Clotting--The First Model of Prothrombin Activation by MASP-1. [PDF]

, 2015
Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity.
Gál, Péter, Lorenz Jenny, Dobó, József, József Dobó, Verena Schroeder, Schroeder, Verena, Jenny, Lorenz, Péter Gál   +7 more
core   +1 more source

Edoxaban Effects on Bleeding Following Punch Biopsy and Reversal by a 4-Factor Prothrombin Complex Concentrate

Circulation, 2015
Background— The oral factor Xa inhibitor edoxaban has demonstrated safety and efficacy in stroke prevention in patients with atrial fibrillation and in the treatment and secondary prevention of venous thromboembolism. This study investigated the reversal
H. Zahir, K. Brown, A. Vandell, Madhuri Desai, J. Maa, V. Dishy, Barbara Lomeli, A. Feussner, Wenqin Feng, Ling He, M. Grosso, H. Lanz, E. Antman   +12 more
semanticscholar   +1 more source

Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K-1) in severe acute liver disease

, 2005
Background/Aims: In patients with severe acute liver dysfunction, i.v. phylloquinone (vitamin K-1) may be given to exclude vitamin K deficiency, rather than impaired hepatic synthesis of coagulation factors alone, as the cause of the coagulopathy ...
Pereira, SP, David Rowbotham, Stephen P. Pereira, Sarah Fitt, Fitt, S, Pereira, S P, Wendon, J, Roger Williams, Williams, R, Julia Wendon, Rowbotham, D, Martin J. Shearer, Shearer, MJ, Shearer, M J   +13 more
core   +1 more source

Factor V Leiden (R506Q), Prothrombin G20210A, and MTHFR C677T Variants and Thrombophilia in Qatar Biobank Participants: A Case Control Study

Pathophysiology
Background: Thrombophilia, a predisposition to develop blood clots, is very common and can have serious sequelae. Aim: This study aimed to determine the prevalence of three thrombophilia-related genetic variants—factor V Leiden (FVL), prothrombin (F2 ...
Sapha Shibeeb, Nada Al-Rayashi, Nehal Shams, Tameem Hadvan, Ejaife O. Agbani, Atiyeh M. Abdallah   +5 more
doaj   +1 more source

The development of a novel native prothrombin assay for the more efficient management of oral anticoagulation therapy [PDF]

, 2004
Disturbances of the natural balance between pro-coagulant and anticoagulant systems, due to hereditary or acquired factors may result in haemorrhagic or thrombotic diseases.
Sylvester, Adrian Jose
core  

Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC

, 2011
Background: Oral anticoagulant therapy (OAT) with warfarin is the standard of stroke prevention in patients with atrial fibrillation. Approximately 30% of patients with cardioembolic strokes are on OAT at the time of symptom onset.
Förch, Christian, Waltraud Pfeilschifter, Daniel Spitzer, Pfeilschifter, Josef (Prof. Dr.), Helmuth Steinmetz, Spitzer, Daniel, Steinmetz, Helmuth, Steinmetz Helmuth, Christian Foerch, Pfeilschifter, Waltraud, Josef Pfeilschifter, Pfeilschifter Waltraud, Spitzer Daniel, Foerch Christian, Pfeilschifter Josef   +14 more
core   +1 more source