Results 41 to 50 of about 190,185 (400)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.

Blood Advances, 2018
Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity.
R. Kremers, S. Zuily, H. Kelchtermans, T. Peters, S. Bloemen, V. Regnault, H. Hemker, P. D. de Groot, D. Wahl, B. de Laat   +9 more
semanticscholar   +1 more source

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis

GE: Portuguese Journal of Gastroenterology, 2023
Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis.
Elze Maria Gomes Oliveira, Ana Cristina de Castro Amaral, Patricia Marinho Costa Oliveira, Valeria Pereira Lanzoni, Renata Mello Perez, Janaina Luz Narciso-Schiavon, Raul Carlos Whale, Roberto Jose Carvalho-Filho, Antonio Eduardo Benedito Silva, Maria Lucia Cardoso Gomes Ferraz   +9 more
doaj   +1 more source

OPTIMIZATION OF THE EVALUATION METHOD OF THE PERFORMANCE OF THERAPY USING INDIRECT ACTION ANTICOAGULANTS [PDF]

Biotechnologia Acta, 2022
Aim. Treatment by indirect anticoagulants (vitamin K antagonists) requires a personalized approach for controlling the overall level of prothrombin and the accumulation of its decarboxylated forms.
D. S. Korolova, O. V. Hornytska, V. A. Deyev, V. I. Gryshchuk, T. M. Chernyshenko, T. M. Platonova, V. O. Chernyshenko   +6 more
doaj   +1 more source

Prothrombin complex concentrates for perioperative vitamin K antagonist and non vitamin K anticoagulant reversal

Anesthesiology, 2018
Vitamin K antagonist therapy is associated with an increased bleeding risk, and clinicians often reverse anticoagulation in patients who require emergency surgical procedures.
J. Levy, J. Douketis, T. Steiner, J. Goldstein, T. Milling   +4 more
semanticscholar   +1 more source

Controle do tempo de protrombina em sangue capilar e venoso em pacientes com anticoagulação oral: correlação e concordância Comparative study of a portable system for prothrombin monitoring using capillary blood against venous blood measurements in patients using oral anticoagulants: correlation and concordance

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: O uso de anticoagulantes orais (ACO) é comum na prática cardiológica, tendo como principais indicações a fibrilação atrial e próteses valvares. Os pacientes em uso de ACO necessitam de controle freqüente do tempo de protrombina (TP).
Tiago Luiz Luz Leiria, Lúcia Campos Pellanda, Eros Magalhães, Gustavo Glotz de Lima   +3 more
doaj   +1 more source

Structure of prothrombin in the closed form reveals new details on the mechanism of activation

Scientific Reports, 2018
The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear.
Mathivanan Chinnaraj, Zhiwei Chen, L. Pelc, Z. Grese, D. Bystranowska, E. Di Cera, N. Pozzi   +6 more
semanticscholar   +1 more source

Efficacy and safety of sorafenib plus vitamin K treatment for hepatocellular carcinoma: A phase II, randomized study

Cancer Medicine, 2021
The previous retrospective study suggested that dosing vitamin K may enhance the anticancer action of sorafenib against hepatocellular carcinoma. To confirm it, we performed a phase II, randomized, open‐label study. Patients with hepatocellular carcinoma
Yoshimichi Haruna, Takayuki Yakushijin, Seiichi Kawamoto   +2 more
doaj   +1 more source

Factor V G1691A (Leiden) is a major etiological factor in Egyptian Budd-Chiari syndrome patients

Turkish Journal of Hematology, 2011
OBJECTIVE: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins). The aim of this study was to determine the prevalence
Tawhida Y. Abdel Ghaffar, Solaf M. Elsayed, Mohamed A. Sakr, Ezzat S. Elsobky, Sara M. Abdelhakam, Said Yousuf, Yonca Eğin, Nejat Akar   +7 more
doaj   +3 more sources

Efficacy and Safety of a 4-Factor Prothrombin Complex Concentrate in Patients on Vitamin K Antagonists Presenting With Major Bleeding A Randomized, Plasma-Controlled, Phase IIIb Study

Circulation, 2013
Background— Patients experiencing major bleeding while taking vitamin K antagonists require rapid vitamin K antagonist reversal. We performed a prospective clinical trial to compare nonactivated 4-factor prothrombin complex concentrate (4F-PCC) with ...
R. Sarode, T. Milling, M. Refaai, A. Mangione, A. Schneider, B. Durn, J. Goldstein   +6 more
semanticscholar   +1 more source