Results 21 to 30 of about 162,806 (305)

Coagulation markers in patients with coronary artery disease

Journal of Biological Research, 2022
Coronary artery disease (CAD) is a major public health problem all over the world, and although diagnostic and treatment approaches are improving, the majority of individuals who suffer CAD will not survive.
Tetiana Marynenko, Tetiana Halenova, Nataliia Raksha, Tetiana Vovk, Yuliya Tyravska, Olexii Savchuk, Liudmyla Ostapchenko   +6 more
doaj   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome

Frontiers in Immunology, 2020
BackgroundCritically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a
Maria Orietta Borghi, Maria Orietta Borghi, Asmaa Beltagy, Asmaa Beltagy, Emirena Garrafa, Emirena Garrafa, Daniele Curreli, Germana Cecchini, Caterina Bodio, Claudia Grossi, Simonetta Blengino, Angela Tincani, Franco Franceschini, Laura Andreoli, Maria Grazia Lazzaroni, Silvia Piantoni, Stefania Masneri, Francesca Crisafulli, Duilio Brugnoni, Maria Lorenza Muiesan, Massimo Salvetti, Gianfranco Parati, Erminio Torresani, Michael Mahler, Francesca Heilbron, Francesca Pregnolato, Martino Pengo, Francesco Tedesco, Nicola Pozzi, Pier Luigi Meroni   +29 more
doaj   +1 more source

Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis [PDF]

, 2002
Hormone replacement therapy (HRT) increases the risk of venous thrombosis. We investigated whether this risk is affected by carriership of hereditary prothrombotic abnormalities.
A. Rumley, Anderson, Bloemenkamp, Daly, E. Daly, F. M. Helmerhorst, F. R. Rosendaal, G. D. O. Lowe, Grady, Grodstein, Hulley, Jick, Kniffin, Lowe, M. Vessey, M. Woodward, Mehta, Nordström, Oger, Rees, Rosendaal, Rosendaal, Silverstein, Stadel, Vandenbroucke, Vessey, Woolf   +26 more
core   +1 more source

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies

Molecules, 2015
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity, Claudia Macaubas, Elizabeth Mellins, Kira Astakhova   +3 more
doaj   +1 more source

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process

Frontiers in Cardiovascular Medicine, 2022
Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai, Cuicui Bai, Joke Konings, Joke Konings, Marisa Ninivaggi, Marcus Lancé, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +8 more
doaj   +1 more source

Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis\ud [PDF]

, 2008
Background: Inherited thrombophilia is only weakly associated with recurrence in patients with a first venous thrombosis (VT). In spite of this, thrombophilia testing is often performed in these patients. Positive results may influence patient management
Coppens, M., Doggen, C.J.M., Middeldorp, S., Reijnders, J.H., Rosendaal, F.R.   +4 more
core   +2 more sources

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis

GE: Portuguese Journal of Gastroenterology, 2023
Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis.
Elze Maria Gomes Oliveira, Ana Cristina de Castro Amaral, Patricia Marinho Costa Oliveira, Valeria Pereira Lanzoni, Renata Mello Perez, Janaina Luz Narciso-Schiavon, Raul Carlos Whale, Roberto Jose Carvalho-Filho, Antonio Eduardo Benedito Silva, Maria Lucia Cardoso Gomes Ferraz   +9 more
doaj   +1 more source

OPTIMIZATION OF THE EVALUATION METHOD OF THE PERFORMANCE OF THERAPY USING INDIRECT ACTION ANTICOAGULANTS [PDF]

Biotechnologia Acta, 2022
Aim. Treatment by indirect anticoagulants (vitamin K antagonists) requires a personalized approach for controlling the overall level of prothrombin and the accumulation of its decarboxylated forms.
D. S. Korolova, O. V. Hornytska, V. A. Deyev, V. I. Gryshchuk, T. M. Chernyshenko, T. M. Platonova, V. O. Chernyshenko   +6 more
doaj   +1 more source

Controle do tempo de protrombina em sangue capilar e venoso em pacientes com anticoagulação oral: correlação e concordância Comparative study of a portable system for prothrombin monitoring using capillary blood against venous blood measurements in patients using oral anticoagulants: correlation and concordance

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: O uso de anticoagulantes orais (ACO) é comum na prática cardiológica, tendo como principais indicações a fibrilação atrial e próteses valvares. Os pacientes em uso de ACO necessitam de controle freqüente do tempo de protrombina (TP).
Tiago Luiz Luz Leiria, Lúcia Campos Pellanda, Eros Magalhães, Gustavo Glotz de Lima   +3 more
doaj   +1 more source