Results 21 to 30 of about 134,214 (298)
Frontiers in Immunology, 2020 BackgroundCritically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a
Maria Orietta Borghi +29 more
doaj +1 more source
Hepatology, EarlyView., 2022 Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai +29 more
wiley +1 more source
, 1981 Clotting and chromogenic assays utilising Echis carinatus venom were set up to determine the total prothrombin-related material (PRM) in plasma and liver fractions.
Linda Jane. Beecroft (7700789)
core +4 more sources
Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies
Molecules, 2015 Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity +3 more
doaj +1 more source
Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process
Frontiers in Cardiovascular Medicine, 2022 Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai +8 more
doaj +1 more source
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Clinical Characteristics of Genuine Acute Autoimmune Hepatitis
GE: Portuguese Journal of Gastroenterology, 2023 Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis.
Elze Maria Gomes Oliveira +9 more
doaj +1 more source
OPTIMIZATION OF THE EVALUATION METHOD OF THE PERFORMANCE OF THERAPY USING INDIRECT ACTION ANTICOAGULANTS [PDF]
Biotechnologia Acta, 2022 Aim. Treatment by indirect anticoagulants (vitamin K antagonists) requires a personalized approach for controlling the overall level of prothrombin and the accumulation of its decarboxylated forms.
D. S. Korolova +6 more
doaj +1 more source
Arquivos Brasileiros de Cardiologia, 2007 FUNDAMENTO: O uso de anticoagulantes orais (ACO) é comum na prática cardiológica, tendo como principais indicações a fibrilação atrial e próteses valvares. Os pacientes em uso de ACO necessitam de controle freqüente do tempo de protrombina (TP).
Tiago Luiz Luz Leiria +3 more
doaj +1 more source
Cancer Medicine, 2021 The previous retrospective study suggested that dosing vitamin K may enhance the anticancer action of sorafenib against hepatocellular carcinoma. To confirm it, we performed a phase II, randomized, open‐label study. Patients with hepatocellular carcinoma
Yoshimichi Haruna +2 more
doaj +1 more source