Results 21 to 30 of about 130,862 (286)

Association of prothrombin, FV Leiden and MTHFR gene polymorphisms in the Montenegrin patients with venous thromboembolism [PDF]

Vojnosanitetski Pregled, 2021
Background/Aim. Polymorphisms of the factor V Leiden (FV G1691A), prothrombin (FII G20210A), and methylene-tetrahydrofolate reductase (MTHFR C677T) genes are the most commonly investigated inherited risk factors for developing venous thromboembolism (VTE)
Teofilov Slađana, Magić Zvonko, Miljanović Olivera, Ostojić Tatjana, Bulatović Milena   +4 more
doaj   +1 more source

Structure of Coagulation Factor II: Molecular Mechanism of Thrombin Generation and Development of Next-Generation Anticoagulants

Frontiers in Medicine, 2018
Coagulation factor II, or prothrombin, is a multi-domain glycoprotein that is essential for life and a key target of anticoagulant therapy. In plasma, prothrombin circulates in two forms at equilibrium, “closed” (~80%) and “open” (~20%), brokered by the ...
Mathivanan Chinnaraj, William Planer, Nicola Pozzi   +2 more
doaj   +1 more source

Thrombophilic molecular markers in young patients (<40 years) with coronary artery disease

Indian Journal of Pathology and Microbiology, 2012
Background: There has been an alarming rise in the incidence of coronary artery disease (CAD) in India especially involving the age group of less than 45 years. In recent past, various studies focused on hemostatic aspects of CAD, but could not determine
Mingma Sherpa, Satendra Sharma, Rajnish Avasthi   +2 more
doaj   +1 more source

Prothrombin Is Responsible for the Lupus Cofactor Phenomenon in a Patient with Lupus Anticoagulant/Hypoprothrombinemia Syndrome

TH Open, 2020
Lupus anticoagulant is a misnomer as it is commonly associated with thromboembolic events. In few cases, the name retains its literal meaning when it characterizes patients with a bleeding disorder.
Vittorio Pengo, Lorena Zardo, Maria Grazia Cattini, Elisa Bison, Elena Pontara, Sara Altinier, Chunyan Cheng, Gentian Denas   +7 more
doaj   +1 more source

Multivariate Analysis of Protein–Nanoparticle Binding Data Reveals a Selective Effect of Nanoparticle Material on the Formation of Soft Corona

Nanomaterials, 2023
When nanoparticles are introduced into the bloodstream, plasma proteins accumulate at their surface, forming a protein corona. This corona affects the properties of intravenously administered nanomedicines.
Susannah Emily Cornwell, Sarah Ogechukwu Okocha, Enrico Ferrari   +2 more
doaj   +1 more source

Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium [PDF]

Vojnosanitetski Pregled, 2005
Background. Venous thrombosis is the most common cause of obstetric morbidity and mortality during pregnancy and puerperium. The incidence of pregnancy associated venous thrombosis varies from 1 in 1000 to 1 in 2000 deliveries. Factor V G1691A (FV Leiden)
Đorđević Valentina, Rakićević Ljiljana B., Spasić Miloš, Miljić Predrag, Miković Danijela, Kovač Mirjana, Radojković Dragica   +6 more
doaj   +1 more source

Coagulation markers in patients with coronary artery disease

Journal of Biological Research, 2022
Coronary artery disease (CAD) is a major public health problem all over the world, and although diagnostic and treatment approaches are improving, the majority of individuals who suffer CAD will not survive.
Tetiana Marynenko, Tetiana Halenova, Nataliia Raksha, Tetiana Vovk, Yuliya Tyravska, Olexii Savchuk, Liudmyla Ostapchenko   +6 more
doaj   +1 more source

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome

Frontiers in Immunology, 2020
BackgroundCritically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a
Maria Orietta Borghi, Maria Orietta Borghi, Asmaa Beltagy, Asmaa Beltagy, Emirena Garrafa, Emirena Garrafa, Daniele Curreli, Germana Cecchini, Caterina Bodio, Claudia Grossi, Simonetta Blengino, Angela Tincani, Franco Franceschini, Laura Andreoli, Maria Grazia Lazzaroni, Silvia Piantoni, Stefania Masneri, Francesca Crisafulli, Duilio Brugnoni, Maria Lorenza Muiesan, Massimo Salvetti, Gianfranco Parati, Erminio Torresani, Michael Mahler, Francesca Heilbron, Francesca Pregnolato, Martino Pengo, Francesco Tedesco, Nicola Pozzi, Pier Luigi Meroni   +29 more
doaj   +1 more source

Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation [PDF]

, 2005
The Scientific Committee of Molecular Biology Techniques (C-MbT) in Clinical Chemistry of the IFCC has initiated a joint project in co-operation with the European Commission, Joint Research Centre, Institute of Reference Materials and Measurements to ...
Tosetto, Alberto, Visvikis, Sophie, RIEGER Sandra, GANCBERG D, Kitchen, Steve, MARKI-ZAY Janos, MANNHALTER C., Schimmel, Heinz G., VISVIKIS S, Gancberg, David, CORBISIER P, REITSMA Pieter, KITCHEN S, TORDAI A, Rieger, Sandra, Halbmayer, Walter-Michael, REITSMA PH, SPANNAGL M, GANCBERG David, Tordai, Attilia, Opplinger Leibundgut, Elisabeth, SPANNAGL Michael, OPPLIGER LEIBUNDGUT E, NEUMAIER Michael, Oppliger Leibundgut, Elisabeth, MELEGH B, CORBISIER Philippe, OLDENBURG Johannes, RIEGER S, Corbisier, Philippe, OLDENBURG J, COOPER S, Leibundgut, Elisabeth Oppliger, HALBMAYER Walter-Michael, Cooper, Susan, HALBMAYER WM, COOPER Susan, KITCHEN Steve, MRKI ZAY J, Reitsma, Pieter H., Marki-Zay, János, Gemmati, Donato, TOSETTO A, VISVIKIS Sophie, TORDAI Attila, Melegh, Béla, Zadro, Renata, SCHIMMEL HG, Neumaier, Michael, KLEIN Christoph, SCHIMMEL Heinz, TOSETTO Alberto, Oldenburg, Johannes, MANNHALTER Christine, ZADRO R, Mannhalter, Christine, Klein, Christoph L., MELEGH Bela, NEUMAIER M, Spannagl, Michael, KLEIN CL, OPPLIGER LEIBUNDGUT Elisabeth, Cooper, S., GEMMATI Donato, ZADRO Renata   +64 more
core   +2 more sources

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies

Molecules, 2015
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity, Claudia Macaubas, Elizabeth Mellins, Kira Astakhova   +3 more
doaj   +1 more source