Results 21 to 30 of about 123,279 (307)

Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC [PDF]

, 2011
Background: Oral anticoagulant therapy (OAT) with warfarin is the standard of stroke prevention in patients with atrial fibrillation. Approximately 30% of patients with cardioembolic strokes are on OAT at the time of symptom onset.
Förch, Christian, Waltraud Pfeilschifter, Daniel Spitzer, Pfeilschifter, Josef (Prof. Dr.), Helmuth Steinmetz, Spitzer, Daniel, Steinmetz, Helmuth, Steinmetz Helmuth, Christian Foerch, Pfeilschifter, Waltraud, Josef Pfeilschifter, Pfeilschifter Waltraud, Spitzer Daniel, Foerch Christian, Pfeilschifter Josef   +14 more
core   +1 more source

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome

Frontiers in Immunology, 2020
BackgroundCritically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a
Maria Orietta Borghi, Maria Orietta Borghi, Asmaa Beltagy, Asmaa Beltagy, Emirena Garrafa, Emirena Garrafa, Daniele Curreli, Germana Cecchini, Caterina Bodio, Claudia Grossi, Simonetta Blengino, Angela Tincani, Franco Franceschini, Laura Andreoli, Maria Grazia Lazzaroni, Silvia Piantoni, Stefania Masneri, Francesca Crisafulli, Duilio Brugnoni, Maria Lorenza Muiesan, Massimo Salvetti, Gianfranco Parati, Erminio Torresani, Michael Mahler, Francesca Heilbron, Francesca Pregnolato, Martino Pengo, Francesco Tedesco, Nicola Pozzi, Pier Luigi Meroni   +29 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

A performance evaluation of commercial fibrinogen reference preparations and assays for Clauss and PT-derived fibrinogen [PDF]

, 2002
The wide availability of fibrinogen estimations based on the prothrombin time (PT-Fg) has caused concern about the variability and clinical utility of fibrinogen assays.
Lowe, G.D.O., P. J. Gaffney, J. Martin, Lawrie, A.S., Howarth, D., G. Purdy, D. Howarth, A. Rumley, I. J. Mackie, Gaffney, P.J., Kitchen, S., Purdy, G., G. D. O. Lowe, S. Kitchen, Rumley, A., A. S. Lawrie, Mackie, I.J., Rigsby, P., P. Rigsby, Martin, J.   +19 more
core   +1 more source

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies

Molecules, 2015
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity, Claudia Macaubas, Elizabeth Mellins, Kira Astakhova   +3 more
doaj   +1 more source

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process

Frontiers in Cardiovascular Medicine, 2022
Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai, Cuicui Bai, Joke Konings, Joke Konings, Marisa Ninivaggi, Marcus Lancé, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +8 more
doaj   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Tissue Prothrombin [PDF]

, 1997
Immunohistochemical analysis of surgically obtained porcine tissue samples reveals ubiquitous staining for prothrombin in organs rich in smooth muscle content and universal staining of smooth muscle in tissue vasculature.
Nancy L. Hassinger, Robert D. McBane, James H. Chesebro, Whyte G. Owen, Yale Nemerson, Randall S. Miller   +5 more
core   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis

GE: Portuguese Journal of Gastroenterology, 2023
Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis.
Elze Maria Gomes Oliveira, Ana Cristina de Castro Amaral, Patricia Marinho Costa Oliveira, Valeria Pereira Lanzoni, Renata Mello Perez, Janaina Luz Narciso-Schiavon, Raul Carlos Whale, Roberto Jose Carvalho-Filho, Antonio Eduardo Benedito Silva, Maria Lucia Cardoso Gomes Ferraz   +9 more
doaj   +1 more source