Reply to "Important Methodological and Statistical Concerns Regarding the Association of Factor V Leiden and MTHFR Polymorphisms With COVID-19 Outcomes". [PDF]
Immun Inflamm DisImmunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
Çıralıoğlu H +7 more
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The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function [PDF]
Chronic Dis Transl MedFlowchart of patient enrollment. ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with hyperhomocysteinemia (HHcy).
Dou X +8 more
europepmc +2 more sources
Important Methodological and Statistical Concerns Regarding the Association of Factor V Leiden and MTHFR Polymorphisms With COVID‐19 Outcomes [PDF]
Immun Inflamm DisImmunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
Panda A.
europepmc +2 more sources
Roadmap for Mental Health Treatment Utilizing Pharmacogenomic Testing: Case Report. [PDF]
Clin Case RepClinical Case Reports, Volume 14, Issue 9, September 2026.
Swanson AP, Mewborn EK, Bae G.
europepmc +2 more sources
MTHFR gene polymorphisms and their biochemical associations with serum vitamin D and IL-17 in ulcerative colitis [PDF]
Journal of Medical BiochemistryBackground: Disturbances in homocysteine metabolism and immune-inflammatory pathways may contribute to the pathogenesis of ulcerative colitis (UC). Methylenetetrahydrofolate reductase (MTHFR) plays a central biochemical role in homocysteine remethylation,
Chen Guang +4 more
doaj +2 more sources
Molecular Dynamics Study of Human MTHFR Wild-Type and A222V Mutant-Type: A Computational Approach
Jurnal Farmasi Sains dan Komunitas, 2023 Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for the homeostasis and metabolism of intracellular folate. However, it is known that one of the commonly found MTHFR gene SNPs (A222V) causes a decrease in activity which decreases ...
Michael Resta Surya Yanuar +2 more
doaj +1 more source
RUDN Journal of Medicine, 2022 In the modern paradigm of public health protection, much attention is paid to the health of women in peri- and postmenopause, and a personalized approach prevails.
Irina S. Zhuravleva +4 more
doaj +1 more source
Неврология, нейропсихиатрия, психосоматика, 2022 Genetic polymorphisms associated with impaired one-carbon metabolism (1-CM) can be a risk factor not only for somatic and neurological diseases, but also for affective disorders (AD).Objective: to compare the frequency of genetic polymorphisms MTHFR, MTR,
E. D. Kasyanov +2 more
doaj +1 more source
Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure. [PDF]
PLoS ONE, 2016 The one-carbon metabolism pathway disorder was important role in successful pregnancy. The MTHFR and TS protein were crucial factor in one-carbon metabolism.
Youngsok Choi +8 more
doaj +1 more source
The Relationship between Homocysteine Levels, MTHFR C677T and A1298C Polymorphism, and Pregnancy Outcomes in Georgian Women with Polycystic Ovary Syndrome: A Case-Control Study [PDF]
International Journal of Fertility and SterilityBackground: Over the past decade, numerous studies have been conducted to determine the role of homocysteineand methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in the pathogenesis of polycystic ovary syndrome(PCOS), yet the results are ...
Elene Asanidze +8 more
doaj +1 more source