Results 21 to 30 of about 26,586 (174)

MTHFR 677C→T polymorphism and risk of coronary heart disease: A meta-analysis

, 2002
CONTEXT: In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD).
THE MTHFR STUDIES COLLABORATION GROUP COAUTHOR, GEMMATI, Donato   +1 more
core   +2 more sources

Correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced NSCLC: A meta-analysis

Pteridines, 2021
The aim of this study was to investigate the correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) by pooling the open published relevant studies.
Han Feng, Xu Wengui
doaj   +1 more source

Maternal methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism and risk of nonsyndromic Cleft lip and/or Palate (NSCL/P) in offspring: A meta-analysis

Asian Journal of Medical Sciences, 2014
Objective: Methyleneterahydrofolate reductase (MTHFR) A1298C polymorphism has been reported a risk factor for nonsyndromic cleft/palate (NSCL/P) in several published articles but results were inconclusive.
Vandana Rai
doaj   +1 more source

Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): The current study aimed to investigate the relationship of genetic polymorphism and plasma methotrexate (MTX) levels, toxicity experience and event free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL).
Mohammad Ali Esmaili, Ahmad Kazemi, Mohammad Faranoush, Hakan Mellstedt, Farhad Zaker, Majid safa, Narjes Mehrvar, Mohammad Reza Rezvany   +7 more
doaj   +1 more source

The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts. [PDF]

, 2008
OBJECTIVE: Epidemiological studies have shown that low folate levels are associated with a high body mass index (BMI). These findings have potentially important health implications and warrant further investigation to determine whether a causal ...
Nordestgaard, B, Tybjaerg-Hansen, A, Lewis, Sarah J, Zacho, J., Lawlor, Debbie A, Ebrahim, S, Smith, G.D., Lewis, S.J., Ebrahim, S., Davey Smith, G, Ebrahim, Shah, Tybjaerg-Hansen, A., Leary, SD, Leary, Sam, Ness, Andy, Lawlor, D, Smith, George Davey, Ness, A., Lewis, SJ, Zacho, J, Zacho, Jeppe, Leary, S., Nordestgaard, Børge G, Nordestgaard, B.G., Tybjaerg-Hansen, Anne, Ness, A, Lawlor, D.A.   +26 more
core   +1 more source

Role of homocysteine metabolism in the development of endothelial dysfunction and hypertension in patients with multiple myeloma

Российский кардиологический журнал, 2022
The article is devoted to the modern understanding of endothelial dysfunction development, the role of hyperhomocysteinemia, and, as a consequence, hypertension in patients with multiple myeloma receiving multiagent chemotherapy.
I. L. Davydkin, E. V. Mordvinova, T. P. Kuzmina, K. V. Naumova, E. S. Fatenkova   +4 more
doaj   +1 more source

Methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and response to 5-FU based chemotherapy in patients with colorectal cancer: a meta-analysis

Pteridines, 2019
Background: Methylene tetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.
Jiang Huafeng, Shen Yi
doaj   +1 more source

Association between MTHFR genetic polymorphism and Parkinson’s disease susceptibility: a meta-analysis

Open Medicine, 2019
Folate metabolism plays quite a critical role in Parkinson’s disease (PD). Previous published research works have studied the link existing between the folate metabolism genetic polymorphisms and PD susceptibility; nevertheless, the results continue ...
Diao Hong-Mei, Song Zheng-Feng, Xu Hai-Dong   +2 more
doaj   +1 more source

The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer’s disease

Open Medicine, 2019
Folate metabolism makes a crucial contribution towards late-onset Alzheimer’s disease (LOAD). Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. We hypothesize that there is an association of C677T
Yi Jian, Xiao Lan, Zhou Sheng-Qiang, Zhang Wen-Jiang, Liu Bai-Yan   +4 more
doaj   +1 more source

Effect of Human MTHFR Gene Polymorphisms in Morbidly Obese Population on Elevate Risk of Type 2 Diabetes

Nano Biomedicine and Engineering, 2018
In this paper, based on the association of methylenetetrahydrofolate reductase (MTHFR) with type 2 diabetes (T2D), we evaluated the association of polymorphism with morbidly obesity on risk type 2 diabetes.
Fatimah Sahib Abed, Hanaa Addai Ali, Omid Ranaei Siadat, Fataneh Fatemi, Sareh Arjmand   +4 more
doaj   +1 more source