Results 1 to 10 of about 5,460 (176)
Fetal MTHFR C677T Polymorphism Confers No Susceptibility to Down Syndrome: Evidence From Meta-Analysis [PDF]
Egyptian Journal of Medical Human Genetics, 2018 Maternal methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is reported as risk factor for Down syndrome (DS) pregnancy but fetal MTHFR C677T polymorphism was not well studied as risk factor for DS.
Vandana Rai, Pradeep Kumar
exaly +4 more sources
Regional distribution of the MTHFR C677T polymorphism in Chinese females
Frontiers in Genetics, 2023 Objective: For analyzing the distribution characteristics of MTHFR C677T polymorphism in Chinese females in order to provide information for reducing birth defects and formulating public health policies to prevent congenital malformations.Methods ...
Hua Lin +4 more
doaj +3 more sources
Interplay among the Variants of One Carbon Metabolism, Methylenetetrahydrofolate Reductase Polymorphisms and Lung Cancer [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Folates perform an integral task in DNA synthesis, methylationand repair. Methylenetetrahydrofolate Reductase (MTHFR) potrays a key part in the metabolism of folate and regulates the equilibrium between the various forms of folate for ...
Mandeep Kaur Sodhi +4 more
doaj +1 more source
Methotrexate effect on biochemical indices of psoriasis patients depends on MTHFR gene polymorphism [PDF]
The Ukrainian Biochemical Journal, 2020 Methotrexate (MTX) is the immunosuppressive anti-inflammatory drug and the antagonist of the enzyme dihydrofolate reductase. Pharmacogenomic studies and clinical evidences suggest that altered response to MTX in patients with different diseases is ...
O. M. Fedota +5 more
doaj +1 more source
BLDE University Journal of Health Sciences, 2023 INTRODUCTION: As per World Health Organization, Infertility is a condition which is characterized by not getting conceived with more than 1-year of unprotected sexual intercourse without usage of any contraceptive aids.
K Ranjith Babu +3 more
doaj +1 more source
International Journal of Technology, 2022 Hypertension has relatively large morbidity and mortality rates throughout the world, including in Indonesia. The prevalence of hypertension tends to be greater in patients with a family history of hypertension.
Tiar Masykuroh Pratamawati +2 more
doaj +1 more source
The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal [PDF]
Disease Markers, 2008 Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results.
Ferro, Anabela +7 more
openaire +3 more sources
Pteridines, 2022 Numerous studies indicated that there exists a relationship between methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and diabetic nephropathy (DN) susceptibility; nonetheless, available proof reported from individual studies has not been ...
Wang Xiaodong, Lan Lejian
doaj +1 more source
PLoS ONE, 2021 Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR
Zhen Li +14 more
doaj +1 more source
C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses [PDF]
Molecular Psychiatry, 1998 A common missense mutation of the methylenetetrahydrofolate reductase (MTHFR) gene (C677T) has been shown to be a risk factor for premature cardiovascular disease and neural tube defect. Deficient activity of MTHFR has also been implicated in the pathogenesis of psychiatric conditions such as schizophrenia and affective disorders.
H, Kunugi +7 more
openaire +2 more sources