Results 11 to 20 of about 5,460 (176)

Analysis of the MTHFR C677T variant with migraine phenotypes [PDF]

BMC Research Notes, 2010
The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common.
Liu, Annie, Menon, Saras, Colson, Natalie, Quinlan, Sharon, Cox, Hannah, Peterson, Madelyn, Tiang, Thomas, Haupt, Larisa, Lea, Rodney, Griffiths, Lyn   +9 more
openaire   +6 more sources

Lack of Association Between the C677T Single Nucleotide Polymorphism of the MTHFR Gene and Glaucoma in Iranian Patients [PDF]

Acta Medica Iranica, 2012
Glaucoma is a major cause of blindness worldwide. A single nucleotide polymorphism of the MTHFR gene (C677T) has been associated with susceptibility to this disease, although this is controversial in the last decade.
Ghasem Fakhraie, Wayne K. Greene, Samira Saee Rad, Reza Raoofian, Sevil Aghapour, Navid Nilforoushan, Mansour Heidari   +6 more
doaj   +4 more sources

The importance of MTHFR C677T/A1298C combined polymorphisms in pulmonary embolism in Turkish population

Medicina, 2016
Background and objective: Pulmonary embolism (PE) is an important cardiovascular emergency with high mortality. There are still problems related to the diagnosis of PE and genetic research may play a key role on diagnosis as well as determining risk ...
Nursah Basol, Nevin Karakus, Asli Yasemen Savas, Ilker Kaya, Kayhan Karakus, Serbulent Yigit   +5 more
doaj   +2 more sources

Association Study of MTHFR Polymorphisms with Nonarteritic Anterior Ischemic Optic Neuropathy in a Spanish Population

Biomedicine Hub, 2020
Introduction: Nonarteritic anterior ischemic optic neuropathy (NAION), painless loss of central and/or peripheral vision, is a multifactorial disease caused by insufficient blood flow through the posterior ciliary arteries to the optic nerve head ...
Beatriz Fernández-Vega, Lydia Álvarez, Montserrat García, Enol Artime, Marta Diñeiro Soto, Javier Nicieza, José A. Vega, Héctor González-Iglesias   +7 more
doaj   +1 more source

Migraine and MTHFR C677T genotype in a population‐based sample [PDF]

Annals of Neurology, 2005
AbstractObjectiveMigraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke.
Scher, AI, Terwindt, GM, Verschuren, WMMrivm, Kruit, MC, Blom, HJ, Kowa, H, Frants, RR, van den Maagdenberg, AMJM, van Buchem, M, Ferrari, MD, Launer, LJ   +10 more
openaire   +5 more sources

The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts. [PDF]

, 2008
OBJECTIVE: Epidemiological studies have shown that low folate levels are associated with a high body mass index (BMI). These findings have potentially important health implications and warrant further investigation to determine whether a causal ...
Nordestgaard, B, Tybjaerg-Hansen, A, Lewis, Sarah J, Zacho, J., Lawlor, Debbie A, Ebrahim, S, Smith, G.D., Lewis, S.J., Ebrahim, S., Davey Smith, G, Ebrahim, Shah, Tybjaerg-Hansen, A., Leary, SD, Leary, Sam, Ness, Andy, Lawlor, D, Smith, George Davey, Ness, A., Lewis, SJ, Zacho, J, Zacho, Jeppe, Leary, S., Nordestgaard, Børge G, Nordestgaard, B.G., Tybjaerg-Hansen, Anne, Ness, A, Lawlor, D.A.   +26 more
core   +1 more source

The combination of methylenehydrofolate reductase C677T polymorphism screening and gastrointestinal tumor markers detection may be an early screening method for gastrointestinal cancer related to helicobacter pylori infection

Genes and Diseases, 2021
Methyltetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, and its single nucleotide polymorphism (SNP) site C677T may be associated with gastrointestinal cancer.
Xiaoxing Wu, Bin Peng, Kun Qian, Wei Zhang, Jiang Min, Mingjun Zhang, Fanling Zeng, Ziwei Wang   +7 more
doaj   +1 more source

MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study. [PDF]

PLoS ONE, 2014
Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal ganglion cells (RGC), which is a characteristic feature of glaucoma.
Shashank Gupta, Pradeep Kumar Bhaskar, Ritu Bhardwaj, Abhishek Chandra, Vidya Nair Chaudhry, Prashaant Chaudhry, Akhtar Ali, Ashim Mukherjee, Mousumi Mutsuddi   +8 more
doaj   +1 more source

Study on the polymorphism of methylenetetrahydrofolate reductase C677T gene as the genetic predisposition of congenital heart disease in North Indian population

Asian Journal of Medical Sciences, 2022
Background: The etiology of congenital heart disease (CHD) is still not known properly. The variant alleles in the methylenetetrahydrofolate reductase (MTHFR) C677T gene help in elevating the serum homocysteine level which is an independent predisposing ...
Amrita Panja , Abhishek Abhinay , Antim Akash Pakhira   +2 more
doaj   +1 more source

MTHFR Gene C677T Polymorphism in Autism Spectrum Disorders [PDF]

Genetics Research International, 2014
Aim. Autism is a subgroup of autism spectrum disorders, classified as a heterogeneous neurodevelopmental disorder and symptoms occur in the first three years of life. The etiology of autism is largely unknown, but it has been accepted that genetic and environmental factors may both be responsible for the disease.
Elif Funda Sener, Didem Behice Oztop, Yusuf Ozkul   +2 more
openaire   +3 more sources