Results 31 to 40 of about 26,586 (174)

MTHFR and Folic Acid

, 2022
 (1)  to assess the association between maternal folic acid fortification and the risk of CHD; (2) to determine the relationship between MTHFR gene polymorphisms and risk of CHD; (3) to explore the interaction effect of maternal MTHFR gene polymorphisms ...
Taowei Zhong (11988209)
core   +1 more source

Analysis of the MTHFR C677T variant with migraine phenotypes [PDF]

, 2010
Background The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura.
Menon Saraswathy, Cox, H, Tiang Thomas, Cox, Hannah, Liu, Annie, Tiang, T, Larisa M Haupt, Quinlan, Sharon, Haupt Larisa M, Lyn R Griffiths, Cox Hannah, Haupt, LM, Lea, RA, Griffiths, Lyn R., Colson Natalie J, Menon, Saras, Peterson, Madelyn, Sharon Quinlan, Hannah Cox, Natalie J Colson, Tiang, Thomas, Lea Rod A, Saraswathy Menon, Griffiths Lyn R, Rod A Lea, Quinlan, S, Peterson, M, Annie Liu, Thomas Tiang, Madelyn Peterson, Colson, Natalie J., Liu, A, Griffiths, LR, Peterson Madelyn, Quinlan Sharon, Menon, S, Liu Annie, Lea, Rod A., Colson, NJ, Haupt, Larisa M.   +39 more
core   +2 more sources

Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism

Global Medical Genetics, 2020
The aim of this study was to investigate the frequency of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in Georgian females with hypothyroidism. Thirty-four patients and 29 healthy individuals were recruited in this study.
Tamar Kvaratskhelia, Elene Abzianidze, Ketevan Asatiani, Merab Kvintradze, Sandro Surmava, Eka Kvaratskhelia   +5 more
doaj   +1 more source

Association Between MTHFR Genetic Variants and Multiple Sclerosis in a Southern Iranian Population [PDF]

International Journal of Molecular and Cellular Medicine, 2015
Multiple sclerosis (MS) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. Genetic predisposition has long been suspected in the etiology of this disease.
Fakhraddin Naghibalhossaini, Hesam Ehyakonandeh, Alireza Nikseresht, Eskandar Kamali   +3 more
doaj  

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

C677T and A1298C Mutations in the Methylenetetrahydrofolate Reductase Gene in Patients with Recurrent Abortion from the Iranian Azeri Turkish [PDF]

International Journal of Fertility and Sterility, 2010
Background To assess whether the C677T and A1298C mutations in the methylenetetrahydrofolate reductase (MTHER) gene are associated with recurrent abortion (RA), we determined the frequencies of the T677 and C1298 mutations in patients and controls ...
Morteza Bagheri, Isa Abdi Rad, Mir Davood Omrani, Fariba Nanbakhsh   +3 more
doaj   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]

, 2015
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Deng, L, Wu, Q, Greene, ND, Leung, KY, Best, A, Mikael, LG, Malysheva, OV, Christensen, KE, Rozen, R, Lévesque, N, Caudill, MA   +10 more
core  

Interaction of MTHFR polymorphism with PAX1 methylation in cervical cancer

Open Life Sciences
We aimed to investigate the roles and interaction effects of high-risk human papillomavirus (HR-HPV) infection, methyltetrahydrofolate reductase (MTHFR) polymorphism, and paired box gene 1 (PAX1) methylation in cervical intraepithelial neoplasia (CIN ...
Zhou Xiao-Yan, Chen Meng-Meng, Yu Jun-mei, Zhou Yang, Luan Yan-Song, Zhang Bing-Qiang, Zhang Yun-Yuan   +6 more
doaj   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source