Clinical Ophthalmology, 2023 Hong Jiang,1,2 Zhiping Liu,1,3 Justin H Townsend,1 Jianhua Wang1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Neurology, University of Miami Miller School of ...
Jiang H, Liu Z, Townsend JH, Wang J
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Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice [PDF]
Frontiers in Aging Neuroscience, 2014 Common functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, a key enzyme in folate and homocysteine metabolism, influence risk for a variety of complex disorders, including developmental, vascular, and neurological diseases ...
Jean-Marie eSontag +6 more
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MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy [PDF]
, 2017 Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for MTX pharmacokinetics.
Gutiérrez Camino, Ángela +5 more
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Joint Metabonomic and Instrumental Analysis for the Classification of Migraine Patients with 677-MTHFR Mutations [PDF]
, 2010 Migraine is a neurological disorder that correlates with an increased risk of cerebrovascular lesions. Genetic mutations of the MTHFR gene are correlated to migraine and to the increased risk of artery pathologies.
LIBONI W +17 more
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Could high serum folate be associated with adverse effects? [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Folate is an important water-soluble vitamin that is presented naturally in foods in particular vegetables, fruits, and whole grains. To which extent is this vitamin needed in our daily regimen is not fully known. Several studies have indicated that many
Mahla Ghorbani +2 more
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Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?
Antioxidants, 2019 Background: Homocysteine is a sulfur amino acid whose metabolism is activated in two pathways: remethylation to methionine, which requires folate and vitamin B12, and transsulfuration to cystathionine, which needs pyridoxal-5’-phosphate.
Caterina Ledda +7 more
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Interplay among the Variants of One Carbon Metabolism, Methylenetetrahydrofolate Reductase Polymorphisms and Lung Cancer [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Folates perform an integral task in DNA synthesis, methylationand repair. Methylenetetrahydrofolate Reductase (MTHFR) potrays a key part in the metabolism of folate and regulates the equilibrium between the various forms of folate for ...
Mandeep Kaur Sodhi +4 more
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Prevalence of thrombophilic mutations in male patients with peripheral arterial disease
Van Tıp Dergisi, 2017 INTRODUCTION: Factor V Leiden (FVL), Prothrombin gene mutation (PT G20210A) and methylenetetrahydrofolate reductase (MTHFR) C677T mutations have been known as thrombophilic risk factors for the development of venous thrombosis.
Meral Ekim, Hasan Ekim
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The importance of folic acid for the health of the human body [PDF]
Farmacja Polska, 2020 A well-balanced diet is undoubtedly a key factor to maintain your body's normal state of health. A deficiency or excess of any nutrient can cause negative effects on human health.
Karolina Jolanta Banyś +2 more
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MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan
Hypertension in Pregnancy, 2023 Objectives This study aimed to investigate the genetic association between MTHFR (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan. Methods A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was pooled for genotyping MTHFR ...
Sadia Mahmood +3 more
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