Results 51 to 60 of about 964,911 (327)

A rare bleeding disorder with severe haemorrhagic manifestation

Asian Journal of Internal Medicine
Factor V is a major part of the coagulation system and maintains a balance in pro-coagulant and anticoagulant pathways. Any deficiency or mutation can lead to disequilibrium in coagulation. Factor V deficiency can be congenital or acquired.
S. Yathukulan, P. Mayurathan, T. Tharshiga   +2 more
doaj   +1 more source

Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study [PDF]

, 2000
In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari ...
Adang, R.P.R. (Rob), Chamuleau, R.A., Haagsma, E.B. (Els), Hattum, J. (Jan) van, Hoek, B. (Bart) van, Janssen, H.L.A. (Harry), Meer, F.J.M. (Felix) van der, Meinardi, J.R., Rosendaal, F.R. (Frits), Uum, S.H. van, Vandenbroucke, J.P. (Jan), Vleggaar, F.P. (Frank)   +11 more
core   +1 more source

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]

, 2014
Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L, Dicorleto, Paul E, Febbraio, Maria, Fox, Paul L, Harding, Clifford V, Hazen, Stanley L, Hise, Amy G, Hu, Bingqing, Li, Xiaoxia, Morton, Richard E, Nagy, Laura E, Ransohoff, Richard M, Roychowdhury, Sanjoy, Schmitt, David, Smith, Jonathan D, Wang, Jian-an, Xiao, Nengming, Yu, Minjia, Zhao, Junjie, Zhou, Hao   +19 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Algorithmic statistics: forty years later [PDF]

, 2017
Algorithmic statistics has two different (and almost orthogonal) motivations. From the philosophical point of view, it tries to formalize how the statistics works and why some statistical models are better than others. After this notion of a "good model"
A Milovanov, A Milovanov, A Shen, A Shen, A Shen, AN Kolmogorov, CH Bennett, CS Wallace, F Mota, J Rissanen, L Antunes, L Antunes, L Bienvenu, L Bienvenu, L Levin, M Koppel, M Koppel, M Li, N Vereshchagin, N Vereshchagin, N Vereshchagin, NK Vereshchagin, NK Vereshchagin, P Gács, P Gács, PMB Vitányi, R Solomonoff, R Solomonoff, S Rooij de, T Cover, VV V’yugin, VV V’yugin, VV V’yugin   +32 more
core   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Pulmonary embolism in a hemophiliac patient with factor V and VIII deficiency: a case report

Journal of Medical Case Reports
Background This is an interesting and unexpected thromboembolic event in a hemophiliac patient. Case presentation This is a case of a 33-year-old primigravidarum of Indian Asian origin with Factor V and Factor VIII deficiency who developed a case of ...
Yap SuHao, Rajeev Vedantham
doaj   +1 more source

Heritable Thrombophilia in Venous Thromboembolism in Northern Pakistan: A Cross-Sectional Study

Advances in Hematology, 2021
Background. Venous thromboembolism (VTE) is referred to as formation of clots in a deep vein or lodging of thrombus towards the lungs which could be fatal yet preventable. The risk of developing VTE can be increased by various factors.
Maria Khan, Chaudhry Altaf, Hamid Saeed Malik, Muhammad Abdul Naeem, Aamna Latif   +4 more
doaj   +1 more source

Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). [PDF]

, 2019
Chronic kidney disease (CKD) is a major cause of morbidity and premature mortality and represents a significant global public health issue. Underlying this burden are the many complications of CKD, including mineral and bone disorders, anemia, and ...
Bino, Avi, Ganz, Tomas, Salusky, Isidro B   +2 more
core  

Algorithmic statistics, prediction and machine learning [PDF]

, 2015
Algorithmic statistics considers the following problem: given a binary string $x$ (e.g., some experimental data), find a "good" explanation of this data. It uses algorithmic information theory to define formally what is a good explanation.
Milovanov, Alexey
core   +2 more sources