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Effect of the Factor V Leiden Mutation on the Clinical Expression of Severe Hemophilia A

Thrombosis and Haemostasis, 2000
SummaryTo determine whether the factor V Leiden mutation is associated with decreased bleeding in individuals with severe hemophilia A, factor concentrate utilization, maximum annual number of bleeding episodes, and the prevalence of hemophilic ...
J. Teitel, I.R. Walker, M. Pai, M. Lam, C. Carter, M.-C. Poon, G. D. Sinclair, J. W. Y. Wu, M. A. Blajchman, S. Reddy, D. Lillicrap, J. Akabutu, G. Growe, B. Ritchie, D.H. Lee   +14 more
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Factor V Leiden: a disorder of factor V anticoagulant function

Current Opinion in Hematology, 2004
Activated protein C (APC) resistance, which is often associated with the factor V R506Q (FV Leiden) mutation, is a common risk factor for venous thrombosis. Study of the mechanism of APC resistance has revealed that coagulation FV stimulates the APC-catalysed inactivation of FVIIIa, and that this anticoagulant function of FV is impaired in FV Leiden ...
Elisabetta, Castoldi, Jan, Rosing
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Diagnosis and management offactor V Leiden

Expert Review of Hematology, 2016
The discovery of the factor V Leiden (FVL) missense mutation (Arg506Gln) causing factor V resistance to the anticoagulant action of activated protein C was a landmark that allowed a better understanding of the basis of inherited thrombotic risk. FVL mutation is currently the most common known hereditary defect predisposing to venous thrombosis.
CAMPELLO, ELENA, SPIEZIA, LUCA, SIMIONI, PAOLO   +2 more
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Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice*

Critical Care Medicine, 2006
The factor V Leiden (FVL) mutation (Arg506Glu) results in the production of an FV protein that when activated is relatively resistant to inactivation by activated protein C and thereby leads to predisposition to thrombosis. The rather high prevalence of the FVL mutation in the general population prompted speculation about a potential survival benefit ...
Brüggemann, Lois W., Schoenmakers, Saskia H. H. F., Groot, Angelique P., Reitsma, Pieter H., Spek, C. Arnold   +4 more
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Factor V Leiden and Perioperative Risk

Anesthesia & Analgesia, 2004
Factor V Leiden (FVL) is the most common known inherited cause of thrombophilia; it is present in approximately 5% of the Caucasian population. Although the risk of venous thrombosis associated with this polymorphism in various medical settings is well described, its effect on perioperative risk is only beginning to be explored. Specifically, there are
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Factor V Leiden Mutation in Pregnancy

Journal of Obstetric, Gynecologic & Neonatal Nursing, 2004
Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations ...
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Screening for the Factor V Leiden Mutation

2003
Familial clustering of thrombosis suggests that genetic risk factors are important in the pathogenesis of venous thromboembolism. However, until recently, well defined genetic defects such as antithrombin, protein C and protein S deficiencies accounted for less than 10% of patients with thrombosis.
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Factor V Leiden

Nursing (Ed. española), 2014
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…About factor V Leiden

Nursing, 2006
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Factor V Leiden paradox

The Lancet, 2000
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