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Factor V Leiden and hemophilia

Thrombosis Research, 2010
Several inherited prothrombotic risk factors have been identified so far. Among them, the factor V (FV) Leiden mutation causes a reduced ability of activated protein C to inactivate activated FV and is the most frequent genetic predisposing factor for venous thromboembolism.
Massimo Franchini
exaly   +5 more sources

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Evolution of Factor V Leiden

Thrombosis and Haemostasis, 2013
SummaryFactor V Leiden is a procoagulant mutation associated with venous and arterial thrombosis and pregnancy complications. Its high prevalence of 5% in Caucasians suggests that there are evolutionary benefits as well. Carriers are indeed reported to have various advantageous phenotypes related to haemostasis, inflammation and fertility: less acute ...
Saskia Middeldorp, Thijs Van Mens
exaly   +3 more sources

Factor V Leiden

Journal of Infusion Nursing, 2009
As one whose family has been affected by factor V Leiden since 1980, the author knows firsthand the impact of this disease process on patients, outcomes, and practice. In today's healthcare environment, genetic screening for the factor V mutation is routine among pregnant women.
Robert J. Desnick, Orlando Guntinas-Lichius, George W. Padberg, Gustav Schonfeld, Xiaobo Lin, Maurizio Averna, Pin Yue, John-John B. Schnog, Victor E. A. Gerdes, Pedro R. Cutillas, Robert J. Unwin, Heike Schulze, Konrad Sandhoff, Jean-François Pellissier, Georges Serratrice, Dominique Figarella-Branger, Cord Sunderkötter, Marcelo Gustavo Binker, Laura Iris Cosen-Binker, Matthias Wettstein, Peter von den Driesch, Rima Nabbout, Massimo Mantegazza, Olivier Dulac, Johann Michael Schröder, Ho Sung Kang, Johann Michael Schröder, Marina Marchetti Hugo Ten Cate, Marina Marchetti, Hugo ten Cate, Lev I. Patrushev, Lee S. Weinstein, Adiba Isa, Fernando Azpiroz, Guang-Sheng Li, Ling Jing, Hui Xu, Anne M. Molloy, John M. Scott, Cord Sunderkötter, Axel Lorentz, Stephan C. Bischoff, Filippo Tamanini, Filippo Tamanini, Thomas Klockgether, Derek A. Wong, Jürgen Kopitz, Carolina von Reitzenstein, Michael Cantz   +48 more
openaire   +3 more sources

Factor V Leiden

JAMA
This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.
Karlyn A, Martin, Mary, Cushman
openaire   +2 more sources

Factor V Leiden and Contraception

Journal of Midwifery & Women's Health, 2004
Factor V Leiden is the most common genetic cause of primary and recurrent venous thromboembolism in women. It is an inherited thrombophilia that results from a genetic mutation. A college‐aged woman who presented for care and had a positive family history of venous thrombosis tested positive for Factor V Leiden.
openaire   +2 more sources

Homozygous factor V Leiden and double heterozygosity for factor V Leiden and prothrombin mutation

Journal of Thrombosis and Thrombolysis, 2012
The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM). Homozygous FVL and PTM have long been feared conditions thought to cause high rates of morbidity and mortality. To analyse clinical features in patients with homozygous FVL and PTM, as well as patients with double heterozygosity for FVL and PTM ...
Ymir, Saemundsson, Signý Vala, Sveinsdottir, Henrik, Svantesson, Peter J, Svensson   +3 more
openaire   +2 more sources

Factor V Leiden: A Clinical Review

The American Journal of the Medical Sciences, 2001
Factor V Leiden is the most prevalent genetic thrombophilia in people of European descent. Since its discovery, much clinical information has been gathered regarding the distribution and prevalence of the genetic mutation, the mechanism of thrombophilia, and its association with clinical thromboembolic events.
Norman M. Kaplan, Biff F. Palmer, Ray Lee   +2 more
openaire   +2 more sources

Factor V Leiden

Dimensions of Critical Care Nursing, 2010
Venous thromboembolism accounts for approximately 600,000 hospitalizations and 50,000 deaths per year in the United States. Many inherited blood disorders predispose patients to this disorder. The most common of these disorders is factor V Leiden. Factor V Leiden thrombophilia is an inherited disorder, mutation, of the mechanisms of blood clotting. The
openaire   +2 more sources

HELLP syndrome and factor V Leiden

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
The association of thrombophilia and obstetrical complications is documented and well consistent with the hypothesis of an insufficient placental perfusion due to fibrin deposition as a major underlying pathophysiological mechanism. Factor V Leiden is one of the most frequent thrombophilic mutations. A high prevalence of this mutation has recently been
M, Bozzo, G, Carpani, L, Leo, S, Marcozzi, E, Sacchi, G, Moroni, G, Pardi   +6 more
openaire   +2 more sources

World distribution of factor V Leiden

The Lancet, 1995
We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations for the presence of factor V Leiden, an important risk factor in venous thromboembolism. The allele frequency in 618 Europeans was 4.4%, with the highest prevalence among Greeks (7%). It was 0.6% in Asia Minor.
D C, Rees, M, Cox, J B, Clegg
openaire   +2 more sources