Results 91 to 100 of about 448,079 (362)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

The relationships between vitamin K and cognition: a review of current evidence [PDF]

, 2019
Vitamin K is a fat-soluble nutrient discovered in 1935 and its role in blood coagulation has been thoroughly explored. In recent years, studies conducted in vitro and on animals highlighted vitamin K involvement in brain cells development and survival ...
Alisi, Ludovico, Cafolla, Arturo, Cao, Roberta, Caramia, Francesca, Cartocci, Gaia, De Angelis, Cristina, Fiorelli, Marco, Librando, Aloisa   +7 more
core   +2 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis and congenital factor VII deficiency: a case report

BMC Medical Genetics, 2018
Background Hemophagocytic lymfohistiocytosis (HLH) is a rare, life-threatening hyperinflammation, characterized by immune system over-activation resulting in hemophagocytosis. HLH could appear as a primary disease caused by mutations of immune-regulatory
Xiong Wang, Ning Tang, Wei Chang, Yanjun Lu, Dengju Li   +4 more
doaj   +1 more source

Factor VII deficiency: a novel missense variant and genotype–phenotype correlation in patients from Southern Italy

Human Genome Variation, 2017
This study aimed at attempting to correlate genotype and phenotype in factor VII deficiency. Here, we present molecular and clinical findings of 10 patients with factor VII deficiency. From 2013 to 2016, 10 subjects were referred to our center because of
G. Tiscia, G. Favuzzi, E. Chinni, D. Colaizzo, L. Fischetti, M. Intrieri, M. Margaglione, E. Grandone   +7 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency

The Turkish Journal of Pediatrics, 2010
We present a case of an atrial septal defect repair under cardiopulmonary bypass in a child with factor VII deficiency. A four-year-old girl, with the diagnosis of secundum atrial septal defect, was referred to surgery. Coagulation tests showed an
Ozan Emiroğlu, Zeynep Eyileten, Tayfun Uçar, Talya Ileri   +3 more
doaj  

Late diagnosed factor VII deficiency – a rare but significant haemorrhagic diathesis

Pediatria Polska
Factor VII (FVII) deficiency is a rare but significant inherited autosomal recessive coagulation disorder, occurring with a frequency of 1 in 300,000-500,000 people.
Karolina Małgorzata Różycka, Beata Kuczyńska, Kinga Podsiadło, Małgorzata Mitura-Lesiuk, Irena Woźnica- Karczmarz   +4 more
doaj   +1 more source

Spectra of observables in the q-oscillator and q-analogue of the Fourier transform [PDF]

, 2005
Spectra of the position and momentum operators of the Biedenharn-Macfarlane q-oscillator (with the main relation aa^+-qa^+a=1) are studied when q>1. These operators are symmetric but not self-adjoint.
Klimyk, Anatoliy
core   +3 more sources

A child with congenital factor VII deficiency [PDF]

Sri Lanka Journal of Child Health, 2009
Sri Lanka Journal of Child Health, 2003; 32: 113-4 (Key words: congenital factor VII deficiency, child) Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4
M Ranjan, H K Welgama
openaire   +2 more sources