Results 11 to 20 of about 12,736,036 (293)
Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo [PDF]
Journal of Thrombosis and Haemostasis, 2014 Jagan Sundaram +5 more
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Direct inhibition of factor VIIa by TFPI and TFPI constructs [PDF]
Journal of Thrombosis and Haemostasis, 2013 Sameera Peraramelli +7 more
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Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet-dependent and -independent mechanisms. [PDF]
J Thromb Haemost, 2020 Keshava S +3 more
europepmc +3 more sources
Tissue factor residues that putatively interact with membrane phospholipids. [PDF]
PLoS ONE, 2014 Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit), bound to the integral membrane protein, tissue factor (the regulatory subunit).
Ke Ke, Jian Yuan, James H Morrissey
doaj +1 more source
Medical Journal Armed Forces India, 2009 Recombinant activated factor VII (rFVIIa) was originally developed for the treatment of hemophilic patients with inhibitors and then used successfully for treating hemorrhages in patients with acquired hemophilia. In the last few years, along with the improvement in the knowledge of its mechanisms of action, rFVIIa has also been used with benefit as a “
P, Kinra, H, Kumar
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Atropisomer Control in Macrocyclic Factor VIIa Inhibitors
Journal of Medicinal Chemistry, 2016 Peter W. Glunz +9 more
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Strain-dependent host transcriptional responses to toxoplasma infection are largely conserved in mammalian and avian hosts [PDF]
, 2011 Toxoplasma gondii has a remarkable ability to infect an enormous variety of mammalian and avian species. Given this, it is surprising that three strains (Types I/II/III) account for the majority of isolates from Europe/North America.
A Khaminets +60 more
core +8 more sources
Inhibitors of Factor VIIa/Tissue Factor [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 The formation of the proteolytic complex composed of the serine protease Factor VIIa and the cell-associated glycoprotein tissue factor (FVIIa/TF) initiates a cascade of amplified zymogen activation reactions leading to thrombus formation. The critical role of the coagulation cascade in pathological thrombosis has been the basis for significant efforts
Rebecca A, Shirk, George P, Vlasuk
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Haematologica, 2015 Standard treatment for Glanzmann thrombasthenia, a severe inherited bleeding disorder, is platelet transfusion. Recombinant factor VIIa is reported to be effective in Glanzmann thrombasthenia with platelet antibodies and/or refractoriness to platelet ...
Man-Chiu Poon +5 more
doaj +1 more source