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International collaborative study for the calibration of a proposed World Health Organization International Standard for thromboplastin, human, recombinant: a report from the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)—Scientific and Standardization Committee (SSC)/ISTH working group on prothrombin time/international normalized ratio standardization [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: The availability of International Reference Preparations for thromboplastins, later on referred to as International Standards (ISs) for thromboplastins is essential for calibration of prothrombin time (PT) measurement systems and for the ...
Michelle P. van der Helm, Claudia J.J. van Rijn, Shanti S. Baktawar, Charmane F. Abdoel, Steve Kitchen, Michelle Bryant, Paula Brown, Armando Tripodi, Erica Scalambrino, Marigrazia Clerici, Petra Herbel, Anja Jünschke, Piet Meijer, Anne Stavelin, Craig Thelwell, Christa M. Cobbaert, Antonius M.H.P. van den Besselaar   +16 more
doaj   +2 more sources

A Novel Thromboplastin-Based Rat Model of Ischemic Stroke

Brain Sciences, 2021
The thromboembolic ischemia model is one of the most applicable for studying ischemic stroke in humans. The aim of this study was to develop a novel thromboembolic stroke model, allowing, by affordable tools, to reproduce cerebral infarction in rats.
Sergei Kalabushev, Ivan Ryzhkov, Zoya Tsokolaeva   +2 more
exaly   +3 more sources

A reproducible rat model for warfarin studies: Prothrombin time assessment with minimal blood using the CoaguChek XS and determination of an effective warfarin dosage [PDF]

Veterinární Medicína
Warfarin research in rats is often challenged by methodological inconsistencies and large blood volume requirements. This study aimed to validate a refined, reproducible rat model for serial prothrombin time (PT) monitoring using the CoaguChek XS, in ...
ET Akyol, MT Hekim, M Erol
doaj   +2 more sources

Determination of Tissue Thromboplastin Activity [PDF]

Haemostasis, 2009
The one-stage prothrombin time test for tissue thromboplastin activity was evaluated using the correction method. A strong influence of the intrinsic system was seen depending on the clotting time and the type of tubes. This test was unsuitable for quantitative comparison of thromboplastin activity of different preparations.Subsequently a two-stage ...
Wijngaards, G., Hemker, H.C.
openaire   +5 more sources

A performance evaluation of commercial fibrinogen reference preparations and assays for Clauss and PT-derived fibrinogen [PDF]

, 2002
The wide availability of fibrinogen estimations based on the prothrombin time (PT-Fg) has caused concern about the variability and clinical utility of fibrinogen assays.
Lowe, G.D.O., Lawrie, A.S., Howarth, D., Rumley, A., Mackie, I.J., Gaffney, P.J., Kitchen, S., Purdy, G., Rigsby, P., Martin, J.   +9 more
core   +9 more sources

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!

Medicina (Lithuania), 2023
Activated partial thromboplastin time (aPTT) is a fundamental screening test for coagulation disturbances. An increased aPTT ratio is quite common in clinical practice.
Rita Carlotta Santoro, Angelo Claudio Molinari, Marzia Leotta   +2 more
exaly   +3 more sources

Saline obtaining and time standardization of prothrombin using thromboplastin of human placenta. [PDF]

Medisur, 2003
Background: Determining prothombine ‘s time is an important lab test in the study of coagulation disorders. To develop this essay the main reactive was thromboplastin , a substance that is presented in tissue and that has been obtained habitually from ...
María de Jesús Sánchez Bouza, Pedro Sánchez Frenes, Albert Vera Razumova, Miriam Soto González, Deysi González Sarría, Junior Jáuregui Solís   +5 more
doaj   +3 more sources

Development and Validation of a Machine Learning Model to Predict Oral Anticoagulant Use in Stroke From Prothrombin Time–International Normalized Ratio and Activated Partial Thromboplastin Time [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Timely recognition of oral anticoagulant use is critical in acute stroke but is often hampered by impaired consciousness and unavailable medication history.
Gaku Fujiwara, Yoshinari Nagakane, Nobukuni Murakami, Eiichi Suehiro, Naoya Hashimoto, Sohei Yoshimura, Kazunori Toyoda, Yohei Okada   +7 more
doaj   +2 more sources

Evaluation of Antiphospholipid Antibodies and Activated Partial Thromboplastin Time in Women with Adverse Outcome of Pregnancy [PDF]

Iranian Journal of Medical Sciences, 2010
Adverse outcome of pregnancy is a potentially dangerouscomplication of conception and affects 15-20% of pregnancies.According to recent studies increased level of bloodantiphospholipids antibodies, if accompanied by predisposingfactors, can be an adverse
Sariyeh Golmahammad lou, Nader Pashapour, Mahnaz khalili, Farzaneh Broomand, Fatemeh Bahadori   +4 more
doaj   +1 more source

The role of hemostatic changes in the pathogenesis of diabetic retinopathy

Journal of Education, Health and Sport, 2022
Introduction: The paper presents the results of the hemostasis system of rats with experimental diabetic retinopathy. Material and methods: Experimental studies were performed on white Wistar rats, which were divided into 2 groups: 1st group – intact
Nataliya Preys, Ivan Savytskyi
doaj   +1 more source