Results 91 to 100 of about 14,336,962 (399)

Extensive Pulmonary Embolism in late pregnancy associated with Anticardiolipin Antibodies [PDF]

, 2004
The leading cause of morbidity and mortality during pregnancy and the puerperium is venous thromboembolism. Though uncommon, the risk is five times higher in a pregnant woman than in a non-pregnant woman of similar age.1,2 In pregnancy, all three ...
Brincat, Mark P., Buhagiar, Louis, Formosa, Mark, Galea, David P., Kunovski, Goce, Samuel, Anthony   +5 more
core  

Heavy hematuria requiring cystectomy in a patient with hemophilia A: a case report and literature review [PDF]

, 2015
BACKGROUND: Hemophilia A is an X-linked recessive disorder caused by a deficiency in factor VIII. Hemophilia A affects 1 in 5,000–10,000 males. Hematuria is frequent in hemophilia.
Kimitoshi Saito, Masaru Hirai, Satoshi Washino, Tomoaki Miyagawa, Yutaka Kobayashi   +4 more
core   +1 more source

Factor VIII products and inhibitor development in severe hemophilia A.

New England Journal of Medicine, 2013
BACKGROUND For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies ...
S. Gouw, J. G. van der Bom, R. Ljung, C. Escuriola, A. Cid, S. Claeyssens-Donadel, C. van Geet, G. Kenet, A. Mäkipernaa, A. Molinari, W. Muntean, R. Kobelt, G. Rivard, E. Santagostino, Angela E. Thomas, H. M. van den Berg   +15 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Prospective longitudinal study of coagulation profiles in children with hypoplastic left heart syndrome from stage I through Fontan completion [PDF]

, 1984
ObjectiveThe risk for thrombosis is increased after the Fontan operation. It is unknown whether children with univentricular heart disease have an intrinsic coagulation anomaly or acquire a defect in coagulation during the course of the staged repair ...
Odegard, Kirsten C., Zurakowski, David, DiNardo, James A., Castro, Robert A., McGowan, Francis X., Neufeld, Ellis J., Laussen, Peter C.   +6 more
core   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Pre-clinical evaluation of an enhanced-function factor VIII variant for durable hemophilia A gene therapy in male mice

Nature Communications
Durable factor VIII expression that normalizes hemostasis is an unrealized goal of hemophilia A adeno-associated virus-mediated gene therapy. Trials with initially normal factor VIII activity observed unexplained year-over-year declines in expression ...
Anna R. Sternberg, Cristina Martos-Rus, Robert J. Davidson, Xueyuan Liu, Lindsey A. George   +4 more
doaj   +1 more source

Preliminary Study Of Immune Tolerance Induction In The Treatment Of Paediatric Haemophilia A With Inhibitors [PDF]

, 2017
Pembentukan antibodi terhadap Factor VIII konsentrat atau lebih dikenali sebagai inhibitor adalah salah satu komplikasi utama dalam perawatan untuk pesakit hemofilia A.
Aziz, Azmanira
core  

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs [PDF]

, 2017
Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists.
A Clauss, A Gatt, A Tripodi, A Zambruni, AF Riddell, AO Spiel, B Agarwal, B Agarwal, B Agarwal, DJ Antoine, DJ Antoine, E Gehrie, EA Sankey, FB Mayr, GC Hugenholtz, H Schochl, HJ Tsai, J Vaquero, JG O’Grady, JH Griffin, KC Lee, KC Lee, L Rinaldi, LA Baker, M Habib, M Senzolo, M Yamaguchi, MJ McPhail, P Chowdary, R Jalan, R Kanel von, RT Stravitz, RT Stravitz, SJ Deventer van, SJ Munoz, SR Ostrowski, T Lisman, T Lisman, TE Warkentin, V Rewari   +39 more
core   +3 more sources