Results 101 to 110 of about 14,299,063 (394)
Hematology Reports, 2013 Development of factor VIII (fVIII)-neutralizing antibodies, called inhibitors, is a challenging problem in the management of hemophilia A patients. We explored the possibility of pretreatment with apoptotic fVIII-expressing embryonic stem (ES) cells to ...
Yoshihiko Sakurai +6 more
doaj +1 more source
CHIANTI - An atomic database for emission lines. XI. EUV emission lines of Fe VII, Fe VIII and Fe IX observed by Hinode/EIS [PDF]
, 2009 A detailed study of emission lines from Fe VII, Fe VIII and Fe IX observed by the EUV Imaging Spectrometer on board the Hinode satellite is presented. Spectra in the ranges 170-212 A and 246-292 A show strongly enhanced lines from the upper solar transition region (temperatures 5.4 <= log T <= 5.9) allowing a number of new line identifications to be ...
arxiv +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Angiogenesis in Squamous Cervical Neoplasia: Comparative Study of two Endothelial Cells [PDF]
, 2001 Purpose: to compare the efficiency of anti-factor VIII and anti-CD34 antibodies as vascular makers in cervical cancer, in cervical intraepithelial neoplasia and in normal cervix.
Baracat, Edmund Chada +4 more
core +5 more sources
Global Journal of Transfusion Medicine, 2019 Introduction: Hemophilia is an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) in hemophilia A (HA) or factor IX (FIX) in hemophilia B (HB).
Sangita Darshan Shah +5 more
doaj +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A. [PDF]
, 2012 nefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production.
Abriss, Daniela +9 more
core +2 more sources
Principles of care for the diagnosis and treatment of von Willebrand disease
Haematologica, 2013 Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in ...
Giancarlo Castaman +2 more
doaj +1 more source
Microrheology and structural quantification of hypercoagulable clots [PDF]
arXiv, 2023 We propose a combination of microrheological and structural characterizations of fibrin networks to study blood hypercoagulability. Fibrin is the central element of coagulation as its polymerization creates the network of fibers in which platelets and red blood cells are included.
arxiv
Factor VIII products and inhibitor development in severe hemophilia A.
New England Journal of Medicine, 2013 BACKGROUND For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies ...
S. Gouw +15 more
semanticscholar +1 more source