Results 111 to 120 of about 14,299,063 (394)

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Suzaku Reveals Helium-burning Products in the X-ray Emitting Planetary Nebula BD+303639 [PDF]

, 2006
BD+303639, the brightest planetary nebula at X-ray energies, was observed with Suzaku, an X-ray observatory launched on 2005 July 10. Using the X-ray Imaging Spectrometer, the K-lines from C VI, O VII, and O VIII were resolved for the first time, and C/O,
Cahn J., de Freitas Pacheco J. A., H. Matsumoto, H. Murakami, J. Kotoku, K. Arnaud, K. Hamaguchi, K. Hayashida, K. Makishima, K. Matsushita, Kreysing H. C., Leuenhagen U., M. Kokubun, M. Murashima, Volk K.   +14 more
core   +3 more sources

Suppression of an Antibody to Factor VIII by a Combination of Factor VIII and Cyclophosphamide [PDF]

Blood, 1971
Abstract A 54-year-old woman with a 20-year history of generalized, severe psoriasis presented with diffuse ecchymoses, melena, and vaginal bleeding. The whole blood clotting time was 59 minutes and the plasma factor VIII concentration was less than 1 per cent of normal.
openaire   +3 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Molecular defects in coagulation Factor VIII and their impact on Factor VIII function [PDF]

, 2002
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74861/1/j.1423-0410.2002.00183.x ...
Acquila, Arai, Ashton, Barrow, Barrowcliffe, David, Duncan, Fay, Fay, Fay, Fay, Fay, Fay, Foster, Gilbert, Gilbert, Gilbert, Gitschier, Hakeos, Healey, Hill-Eubanks, Hill-Eubanks, Hoyer, Kamisue, Keeling, Lapan, Lapan, Laub, Lenting, Lollar, Mann, Nesbitt, Nesheim, Nogami, Nogami, Pemberton, Pipe, Pipe, Pipe, Pock, Pock, Pratt, Raut, Raut, Regan, Saenko, Saenko, Saenko, Saenko, Saenko, Saenko, Saenko, Saenko, Sandberg, Sandberg, Sawamoto, Scandella, Schwaab, Schwaab, Shima, Shima, Shima, Stoilova-McPhie, Van Dieijen   +63 more
core   +1 more source

Detection of Ne VIII in an Intervening Multi-Phase Absorption System Towards 3C 263 [PDF]

, 2009
We report on the detection of Ne VIII in an intervening multiphase absorption line system at z=0.32566 in the FUSE spectrum of the quasar 3C 263. The Ne VIII 770 A line detection has a 3.9 sigma significance. At the same velocity we also find absorption lines from C IV, O III, O IV and N IV. The line parameter measurements yield log [N(Ne VIII), cm^-2]
arxiv   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Extensive Pulmonary Embolism in late pregnancy associated with Anticardiolipin Antibodies [PDF]

, 2004
The leading cause of morbidity and mortality during pregnancy and the puerperium is venous thromboembolism. Though uncommon, the risk is five times higher in a pregnant woman than in a non-pregnant woman of similar age.1,2 In pregnancy, all three ...
Brincat, Mark P., Buhagiar, Louis, Formosa, Mark, Galea, David P., Kunovski, Goce, Samuel, Anthony   +5 more
core  

Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms

Haematologica, 2018
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development.
Maria T. Georgescu, Paul C. Moorehead, Alice S. van Velzen, Kate Nesbitt, Birgit M. Reipert, Katharina N. Steinitz, Maria Schuster, Christine Hough, David Lillicrap   +8 more
doaj   +1 more source

Dirac Neutrino Anapole Moment [PDF]

, 2002
We calculate the Dirac neutrino anapole moment (a_{\nu_l}) in the context of the Standard Model (SM) making use of the Dirac form factor F_D(q^2) introduced recently by J. Bernabeu, L. G. Cabral-Rosetti, J. Papavassiliou y J. Vidal by using the Pinch Technique (PT) formalism, working in two different gauge-fixing schemes (R_\xi guage and the ...
arxiv   +1 more source