Results 141 to 150 of about 1,958,128 (299)

Potential role of a new PEGylated recombinant factor VIII for hemophilia A

Journal of Blood Medicine, 2016
Tung Thanh Wynn,1 Burak Gumuscu,2,3 1Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, 2Pediatric Hematology-Oncology, Bon Secours Health System, St.
Wynn TT, Gumuscu B
doaj  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Spontaneous Inhibitors of Factor VIII (Antihemophilic Factor) [PDF]

Acta Medica Iranica, 1971
Fereydoun Ala, Irandokht Shoa'i   +1 more
doaj   +1 more source

High-precision $\alpha_s$ measurements from LHC to FCC-ee

, 2015
This document provides a writeup of all contributions to the workshop on "High precision measurements of $\alpha_s$: From LHC to FCC-ee" held at CERN, Oct. 12--13, 2015.
Alekhin, S., Banfi, A., Bethke, S., Blümlein, J., Chetyrkin, K. G., d'Enterria, D., d'Enterria, David, Dissertori, G., Hoang, A. H., Klasen, M., Klijnsma, T., Kluth, S., Kneur, J. -L., Kniehl, B. A., Kolodrubetz, D. W., Kühn, J., Mackenzie, P., Malaescu, B., Mateu, V., Mihaila, L., Moch, S., Mönig, K., Perez-Ramos, R., Pich, A., Pires, J., Rabbertz, K., Riera, J. Soto i, Salam, G. P., Sannino, F., Skands, Peter Z., Srebre, M., Stewart, I. W., Tormo, X. Garcia i   +32 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice. [PDF]

Bone Res
Babuty A, Muñoz-Garcia J, Christophe OD, Fradet L, Taupin M, Cochonneau D, Ollivier E, Driessler F, Lange C, Boychenko O, Heymann MF, Heymann D.   +11 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Importancia del diagnóstico de portadoras en familias con antecedentes de hemofilia

Revista Cubana de Hematología, Inmunología y Hemoterapia
La hemofilia es una enfermedad hemorrágica hereditaria ligada al cromosoma X que se presenta debido a mutaciones en los genes del factor VIII (hemofilia A) y el factor IX (hemofilia B), que ocasiona una disminución o deficiencia funcional de estas ...
Kalia Lavaut Sánchez
doaj  

Influence of Coagulation Factor VIII on Ischemic Stroke. [PDF]

Rev Neurol
Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P, Arjona-Padillo A.   +3 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source