Results 181 to 190 of about 257,618 (243)

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men, Hui Li, Zhuoxin Guo, Bin Qin, Hengfang Ruan, Ruipeng Cai, Bingjun Zhang, Aimin Wu, Lei Wei, Yongqiang Dai, Haiyan Li, Zhengqi Lu   +11 more
wiley   +1 more source

Efanesoctocog alfa: the renaissance of Factor VIII replacement therapy.

Haematologica
Dargaud Y, Leuci A, Ruiz AR, Lacroix-Desmazes S.   +3 more
europepmc   +1 more source

A phase 1/2 safety and efficacy study of TAK-754 gene therapy: The challenge of achieving durable factor VIII expression in haemophilia A clinical trials. [PDF]

Haemophilia
Chapin J, Álvarez Román MT, Ayash-Rashkovsky M, Diogo D, Kenniston J, Lopez-Jaime FJ, Maggiore C, Mingot-Castellano ME, Rajavel K, Rauch A, Susen S, von Grotthuss M, Wagoner M, Wang Q.   +13 more
europepmc   +1 more source

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source

Efanesoctocog Alfa versus Standard and Extended Half-Life Factor VIII Prophylaxis in Adolescent and Adult Patients with Haemophilia A without Inhibitors. [PDF]

Adv Ther
Klamroth R, Kragh N, Arnaud A, Guyot P, Wilson A, Wojciechowski P, Wdowiak M, Margas W, Bystrická L, Tosetto A.   +9 more
europepmc   +1 more source

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

Arthritis Care &Research, EarlyView.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur, Georgina Nakafero, Abhishek Abhishek, Christian Mallen, Michael Doherty, Weiya Zhang   +5 more
wiley   +1 more source

Left Ventricular Thrombus With Silent Myocardial Infarction in a Patient With Factor V Leiden Mutation and High Factor VIII Levels: A Case Report. [PDF]

Cureus
Zahid AS, Shariff M, Huggett R.
europepmc   +1 more source

Association of Changes in Hand Pain With BMI, Employment, and Mental Well‐Being Over Four Years in Patients With Hand Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective We aimed to characterize patients with hand osteoarthritis (OA) with deteriorating or improving hand pain and to investigate patients achieving good clinical outcome after four years. Methods We used four‐year annual Australian/Canadian Hand Osteoarthritis Index (AUSCAN) pain subscale (range 0–20) measurements from the Hand OSTeoArthritis in ...
Coen van der Meulen, Lotte A. van de Stadt, Saskia J. Buck, Frits R. Rosendaal, Sietse E. S. Terpstra, Margreet Kloppenburg   +5 more
wiley   +1 more source

Effect of factor VIII and FVIII/PC ratio on portal vein thrombosis in liver cirrhosis: a systematic review and meta‑analysis. [PDF]

BMC Gastroenterol
Wu Z, Xiao Y, Qi Z, Guo T, Tong H, Wang Y.   +5 more
europepmc   +1 more source

Pregnancy Outcomes of Targeted Synthetic Disease‐Modifying Antirheumatic Drugs Among Patients With Autoimmune Diseases: A Scoping Review

Arthritis Care &Research, EarlyView.
Objective Targeted synthetic disease‐modifying antirheumatic drugs (tsDMARDs) have expanded the management of autoimmune diseases, including rheumatic diseases. As the use of these drugs grows, it is important to understand their effects on pregnancy.
Vienna Cheng, Neda Amiri, Vicki Cheng, Ursula Ellis, Jacquelyn J. Cragg, Mark Harrison, Laurie Proulx, Mary A. De Vera   +7 more
wiley   +1 more source