Results 11 to 20 of about 14,299,063 (394)

The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells

Haematologica, 2017
The development of inhibitory antibodies to therapeutic factor VIII is the major complication of replacement therapy in patients with hemophilia A. The first step in the initiation of the anti-factor VIII immune response is factor VIII interaction with ...
Bagirath Gangadharan, Mathieu Ing, Sandrine Delignat, Ivan Peyron, Maud Teyssandier, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes   +6 more
doaj   +2 more sources

von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII

Haematologica, 2016
It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived ...
Nicoletta Sorvillo, Robin B. Hartholt, Esther Bloem, Magdalena Sedek, Anja ten Brinke, Carmen van der Zwaan, Floris P. van Alphen, Alexander B. Meijer, Jan Voorberg   +8 more
doaj   +2 more sources

Extrahepatic sources of factor VIII potentially contribute to the coagulation cascade correcting the bleeding phenotype of mice with hemophilia A

Haematologica, 2015
A large fraction of factor VIII in blood originates from liver sinusoidal endothelial cells although extrahepatic sources also contribute to plasma factor VIII levels.
Diego Zanolini, Simone Merlin, Maria Feola, Gabriella Ranaldo, Angela Amoruso, Gianluca Gaidano, Mauro Zaffaroni, Alessandro Ferrero, Sandra Brunelleschi, Guido Valente, Sanjeev Gupta, Maria Prat, Antonia Follenzi   +12 more
doaj   +2 more sources

Highly Ionized Collimated Outflow from HE 0238 - 1904 [PDF]

, 2012
We present a detailed analysis of a highly ionized, multiphased and collimated outflowing gas detected through O V, O VI, Ne VIII and Mg X absorption associated with the QSO HE 0238 - 1904 (z_em ~ 0.629).
A. Narayanan, Arav, Asplund, B. D. Savage, Bentz, Bower, Crenshaw, Dai, Faucher-Giguère, Ferland, G. C. Dewangan, Ganguly, Gnat, Green, Gupta, Hall, Hamann, Hamann, Hamann, Hamann, King, Korista, Korista, Moos, Ojha, Onken, Osterman, Petitjean, Piconcelli, R. Srianand, S. Muzahid, Sahnow, Sambruna, Silk, Srianand, Stalin, Telfer, Telfer, V. Mohan, Verner, Vivek   +40 more
core   +2 more sources

Scale-factor duality in string Bianchi cosmologies [PDF]

Int.J.Mod.Phys. D8 (1999) 349-361, 1999
We apply the scale factor duality transformations introduced in the context of the effective string theory to the anisotropic Bianchi-type models. We find dual models for all the Bianchi-types [except for types $VIII$ and $IX$] and construct for each of ...
Copeland E. J., ELISA DI PIETRO, Harvey A., JACQUES DEMARET   +3 more
core   +5 more sources

Cosmic Origins Spectrograph Observations of Warm Intervening Gas Towards 3C263 [PDF]

, 2012
We present HST/COS high S/N observations of the z = 0.32566 multi-phase absorber towards 3C263. The COS data shows absorption from H I, O VI, C III, N III, Si III and C II. The Ne VIII in this absorber is detected in the FUSE spectrum.
Narayanan, Anand, Savage, Blair D., Wakker, Bart P.   +2 more
core   +2 more sources

Alloantibodies to therapeutic factor VIII in hemophilia A: the role of von Willebrand factor in regulating factor VIII immunogenicity

Haematologica, 2015
The rising incidence of neutralizing antibodies (inhibitors) against therapeutic factor VIII prompted the conduct of studies to answer the question as to whether this rise is related to the introduction of recombinant factor VIII products.
Johannes Oldenburg, Sébastien Lacroix-Desmazes, David Lillicrap   +2 more
doaj   +2 more sources

Impact of being underweight or overweight on factor VIII dosing in hemophilia A patients

Haematologica, 2013
Since 1981, the number of factor VIII units to infuse into patients with hemophilia A in order to achieve adequate circulating factor VIII levels has been calculated using the formula: [body weight(kg)×desired factor VIII increase(%)]/2, assuming a ...
Séverine Henrard, Niko Speybroeck, Cedric Hermans   +2 more
doaj   +2 more sources

Deuteron Electromagnetic Properties with a Poincar\'e-Covariant Current Operator within Front-Form Hamiltonian Dynamics [PDF]

, 2001
Deuteron elastic and deep inelastic electromagnetic properties have been studied within the front-form Hamiltonian dynamics, using a Poincar\'e-covariant current operator. The deuteron elastic form factors are strongly sensitive to different realistic $N-
Pace, E., Salme`, G.
core   +4 more sources

Recombinant Factor VIII Concentrates [PDF]

Seminars in Thrombosis and Hemostasis, 2010
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Franchini, Massimo, Lippi, Giuseppe
core   +7 more sources