Results 11 to 20 of about 4,751,108 (302)
The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells
Haematologica, 2017 The development of inhibitory antibodies to therapeutic factor VIII is the major complication of replacement therapy in patients with hemophilia A. The first step in the initiation of the anti-factor VIII immune response is factor VIII interaction with ...
Bagirath Gangadharan +6 more
doaj +1 more source
Haematologica, 2016 It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived ...
Nicoletta Sorvillo +8 more
doaj +1 more source
Frontiers in Immunology, 2020 The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on ...
Sandrine Delignat +8 more
doaj +1 more source
Pakistan Armed Forces Medical Journal, 2021 Objective: To evaluate the efficacy of recombinant factor VIII FC fusion protein in haemophilia A patient receiving on demand treatment only. Study Design: Comparative cross sectional study.
Saima Zahir +5 more
doaj +1 more source
Identification of Key Coagulation Activity Determining Elements in Canine Factor VIII
Molecular Therapy: Methods & Clinical Development, 2020 It is well known that canine factor VIII (cFVIII) has a higher specific activity than does human FVIII (hFVIII), and it has been previously demonstrated that cFVIII light chain is able to enhance hFVIII activity.
Jenni Firrman +11 more
doaj +1 more source
Case Reports in Rheumatology, 2021 Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency
Christine Loftis +2 more
doaj +1 more source
Calcium Prevents Enhanced Degradation of Factor VIII in the Condition of Motion
Biology, 2023 Background: Hemophilia A and B induce recurrent bleeding episodes, mainly in skeletal muscles and joints that are in intermittent motion. We have previously demonstrated that intermittent motion contributes to increased degradation of factors VIII and IX.
Haim Cohen +5 more
doaj +1 more source
BMJ, 1995 Patients with haemophilia A lack only factor VIII. Why give them anything else as replacement treatment? Previously the answer to this question was determined largely by the practical difficulty in separating factor VIII from fibrinogen, fibronectin, and immunoglobulins, so that concentrates contained 2000 U/mg respectively, but concentrates prepared ...
E G, Tuddenham, M, Laffan
openaire +2 more sources
Impact of being underweight or overweight on factor VIII dosing in hemophilia A patients
Haematologica, 2013 Since 1981, the number of factor VIII units to infuse into patients with hemophilia A in order to achieve adequate circulating factor VIII levels has been calculated using the formula: [body weight(kg)×desired factor VIII increase(%)]/2, assuming a ...
Séverine Henrard +2 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2021 The most serious complication of factor VIII (FVIII) replacement therapy is the occurrence of anti‐FVIII alloantibodies that can strongly reduce or abolish the effect of human FVIII products.
Yesim Dargaud +1 more
doaj +1 more source