Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking [PDF]
Haematologica, 2017 Factor VIII C-domains are believed to have specific functions in cofactor activity and in interactions with von Willebrand factor. We have previously shown that factor VIII is co-targeted with von Willebrand factor to the Weibel-Palade bodies in blood ...
Eduard H.T.M. Ebberink +7 more
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Many factor VIII products available in the treatment of hemophilia A: an embarrassment of riches?
Journal of Blood Medicine, 2017 Kenneth Lieuw1,2 1Department of Pediatrics, Walter Reed National Military Medical Center, 2Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Abstract: Hemophilia A (HA) is a common bleeding disorder caused ...
Lieuw K
doaj +1 more source
Prolonged elevations in haemostatic and rheological responses following psychological stress in low socioeconomic status men and women [PDF]
, 2003 Low socioeconomic status (SES) and psychological stress are associated with increased risk of coronary heart disease, and both may influence haemostatic responses.
Lowe, G.D.O. +7 more
core +5 more sources
Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A. [PDF]
, 2012 nefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production.
Tonn, Torsten +29 more
core +1 more source
Spontaneous bleeding in a patient with malignant lymphoma: A case of acquired hemophilia [PDF]
, 2000 Background: Acquired hemophilia is a rare condition which can be associated with lymphoproliferative disease. Case Report: Eleven yea rs after the diagnosis of immunocytoma had been made, a 72-year-old man developed a high-titer factor VIII inhibitor. At
Brack, N. +5 more
core +1 more source
Identification of Key Coagulation Activity Determining Elements in Canine Factor VIII
Molecular Therapy: Methods & Clinical Development, 2020 It is well known that canine factor VIII (cFVIII) has a higher specific activity than does human FVIII (hFVIII), and it has been previously demonstrated that cFVIII light chain is able to enhance hFVIII activity.
Jenni Firrman +11 more
doaj +1 more source
Calcium Prevents Enhanced Degradation of Factor VIII in the Condition of Motion
Biology, 2023 Background: Hemophilia A and B induce recurrent bleeding episodes, mainly in skeletal muscles and joints that are in intermittent motion. We have previously demonstrated that intermittent motion contributes to increased degradation of factors VIII and IX.
Haim Cohen +5 more
doaj +1 more source
BMJ, 1995 Patients with haemophilia A lack only factor VIII. Why give them anything else as replacement treatment? Previously the answer to this question was determined largely by the practical difficulty in separating factor VIII from fibrinogen, fibronectin, and immunoglobulins, so that concentrates contained 2000 U/mg respectively, but concentrates prepared ...
E G, Tuddenham, M, Laffan
openaire +2 more sources
Research and Practice in Thrombosis and Haemostasis, 2021 The most serious complication of factor VIII (FVIII) replacement therapy is the occurrence of anti‐FVIII alloantibodies that can strongly reduce or abolish the effect of human FVIII products.
Yesim Dargaud +1 more
doaj +1 more source
Impact of being underweight or overweight on factor VIII dosing in hemophilia A patients
Haematologica, 2013 Since 1981, the number of factor VIII units to infuse into patients with hemophilia A in order to achieve adequate circulating factor VIII levels has been calculated using the formula: [body weight(kg)×desired factor VIII increase(%)]/2, assuming a ...
Séverine Henrard +2 more
doaj +1 more source