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[7] Factor VIII and factor VIIIa
1993Publisher Summary This chapter focuses on the role of factor VIII and factor VIIIa present in blood. The factor VIIIa apparently alters the active site structure of factor IXa to make it recognize the rate-limiting transition state for factor X activation, because its dominant kinetic effect is to increase the kcat.
Philip J. Fay +2 more
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Characteristics of the Factor VIII Protein and Factor XIII in Various Factor VIII Concentrates
Scandinavian Journal of Haematology, 1980The in vitro properties of 5 factor VIII preparations (AHF‐Kabi, Hemofil Hyland, AHF‐Profilate Abbott, Kryobulin Immuno and Factorate High Purity Armour) and an ordinary cryoprecipitate were studied with reference to factor VIII clotting activity (VIII:C), factor VIII clotting antigen (VIILCAg), factor VIII related antigen (VIIIR:Ag) (EI, IRMA, CIE ...
Lars Holmberg +3 more
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The Absorption of Human Factor VIII Neutralizing Antibody by Factor VIII
British Journal of Haematology, 1974Summary. A new technique has been devised for measuring the amount of human factor VIII neutralizing antibody that is absorbed by factor VIII. The method has been applied to factor VIII from normal donors and to factor VIII‐like antigen from haemophilic persons.
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Porcine Factor VIII in Factor VIII Antibody-Positive Hemophiliacs
Journal of Interferon Research, 1994rected against the factor VIII protein, and completely or partially neutralizing the plasma coagulant activity of the clotting factor, is associated with a variety of diseases, and these antibodies are often the cause of the life-threatening bleeds. Such inhibitors, designated as acquired hemophilia, are uncommon (found in 0.2-1.0 previously normal ...
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Thrombosis and Haemostasis, 1997 Mimicking Factor VIII to Manage the Factor VIII–Deficient State
New England Journal of Medicine, 2018Hemophilia A is an X-linked disorder caused by defective factor VIII, which until now has involved factor VIII replacement to treat and prevent bleeding in joints, muscles, and other body cavities....
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Factor VIII replacement is still the standard of care in haemophilia A.
Blood transfusion = Trasfusione del sangue, 2019L. Aledort +3 more
semanticscholar +1 more source
1992
Factor VIII activity has been historically measured with two types of methods: the one-stage assay, based on the activated partial thromboplastin time (APTT) (Chapter 5) and the two-stage assay, based on the thromboplastin generation test. The relative merits of the two assays have been debated1,2.
P. M. Mannucci, A. Tripodi
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Factor VIII activity has been historically measured with two types of methods: the one-stage assay, based on the activated partial thromboplastin time (APTT) (Chapter 5) and the two-stage assay, based on the thromboplastin generation test. The relative merits of the two assays have been debated1,2.
P. M. Mannucci, A. Tripodi
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New England Journal of Medicine, 1974
Physicians not engaged in the treatment of patients with bleeding disorders may not fully appreciate the magnitude of the revolution that has occurred in the management of classic hemophilia. Before 1964 the mainstay of therapy was fresh-frozen plasma. Limited by the volume of plasma that could be given, treatment was usually inadequate.
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Physicians not engaged in the treatment of patients with bleeding disorders may not fully appreciate the magnitude of the revolution that has occurred in the management of classic hemophilia. Before 1964 the mainstay of therapy was fresh-frozen plasma. Limited by the volume of plasma that could be given, treatment was usually inadequate.
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