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Mimicking Factor VIII to Manage the Factor VIII–Deficient State
New England Journal of Medicine, 2018Hemophilia A is an X-linked disorder caused by defective factor VIII, which until now has involved factor VIII replacement to treat and prevent bleeding in joints, muscles, and other body cavities....
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1992
Factor VIII activity has been historically measured with two types of methods: the one-stage assay, based on the activated partial thromboplastin time (APTT) (Chapter 5) and the two-stage assay, based on the thromboplastin generation test. The relative merits of the two assays have been debated1,2.
P. M. Mannucci, A. Tripodi
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Factor VIII activity has been historically measured with two types of methods: the one-stage assay, based on the activated partial thromboplastin time (APTT) (Chapter 5) and the two-stage assay, based on the thromboplastin generation test. The relative merits of the two assays have been debated1,2.
P. M. Mannucci, A. Tripodi
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Factor VIII Structure and Function
Thrombosis and Haemostasis, 1993Factor VIII, a non-covalent heterodimer comprised of a heavy chain (A1-A2-B domains) and light chain (A3-C1-C2 domains), circulates as an inactive procofactor in complex with von Willebrand factor. Metal ions are critical to the integrity of factor VIII, with Cu and Ca ions stabilizing the heterodimer and generating the active conformation ...
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New England Journal of Medicine, 1974
Physicians not engaged in the treatment of patients with bleeding disorders may not fully appreciate the magnitude of the revolution that has occurred in the management of classic hemophilia. Before 1964 the mainstay of therapy was fresh-frozen plasma. Limited by the volume of plasma that could be given, treatment was usually inadequate.
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Physicians not engaged in the treatment of patients with bleeding disorders may not fully appreciate the magnitude of the revolution that has occurred in the management of classic hemophilia. Before 1964 the mainstay of therapy was fresh-frozen plasma. Limited by the volume of plasma that could be given, treatment was usually inadequate.
openaire +3 more sources