Results 41 to 50 of about 1,888,340 (371)
Haematologica, 2019 Therapeutic factor VIII is highly immunogenic. Despite intensive research in the last decades, the reasons why 5-30% of patients with hemophilia A (of all severities) develop inhibitory anti-factor VIII antibodies (inhibitors) following replacement ...
Aditi Varthaman +1 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2021 The most serious complication of factor VIII (FVIII) replacement therapy is the occurrence of anti‐FVIII alloantibodies that can strongly reduce or abolish the effect of human FVIII products.
Yesim Dargaud +1 more
doaj +1 more source
The inactivation of factor VIII in vitro [PDF]
, 1972 When normal citrated plasma is stored at 37° C and pH 7.8 the factor VIII activity drops to about 50% of its initial value during the first 8-12 h. In the following 4 days practically no further drop in activity is found.
Hemker, H.C. +2 more
core +2 more sources
Haematologica, 2015 A large fraction of factor VIII in blood originates from liver sinusoidal endothelial cells although extrahepatic sources also contribute to plasma factor VIII levels.
Diego Zanolini +12 more
doaj +1 more source
Where Are the Baryons? III: Non-Equilibrium Effects and Observables [PDF]
Astrophys.J.650:573-591,2006, 2005 Numerical simulations of the intergalactic medium have shown that at the present epoch a significant fraction (40-50%) of the baryonic component should be found in the (T~10^6K) Warm-Hot Intergalactic Medium (WHIM) - with several recent observational lines of evidence indicating the validity of the prediction.
arxiv +1 more source
Self-ionizing galactic winds [PDF]
, 2022 We present hydrodynamical simulations of galactic winds from star-forming galaxies including non-equilibrium ionization and frequency-dependent radiative transfer, processes that have remained largely unaccounted for in galactic wind studies. We consider radiation from massive stars, the metagalactic UV/X-ray background, and the self-radiation of the ...
arxiv +1 more source
Attempted spleen transplant in classical hemophilia [PDF]
, 1969 Recent evidence has indicated that the spleen may be partly responsible for synthesis or storage of antihemophilic factor (factor VIII) in dogs (8) and in man (2). Transplantation of the spleen into dogs with congenital deficiency of factor VIII has been
Githens, JH +5 more
core +1 more source
Haematologica, 2017 Factor VIII C-domains are believed to have specific functions in cofactor activity and in interactions with von Willebrand factor. We have previously shown that factor VIII is co-targeted with von Willebrand factor to the Weibel-Palade bodies in blood ...
Eduard H.T.M. Ebberink +7 more
doaj +1 more source
The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces. [PDF]
PLoS ONE, 2015 The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy
Caileen M Brison +8 more
doaj +1 more source
Importance of factor-IX-dependent prothrombinase formation - the Josso Pathway,- in clotting plasma [PDF]
, 1989 We report a study on the importance of factor IX activation in thromboplastin-dependent coagulation in plasma. Diluted, CaCl2-containing thromboplastin solutions at constant phospholipid concentration were used to trigger the coagulation in plasma from ...
Beguin, S., Hemker, H.C., Xi, Ma
core +2 more sources