Results 41 to 50 of about 257,618 (243)

Microrheology and structural quantification of hypercoagulable clots [PDF]

open access: yesarXiv, 2023
We propose a combination of microrheological and structural characterizations of fibrin networks to study blood hypercoagulability. Fibrin is the central element of coagulation as its polymerization creates the network of fibers in which platelets and red blood cells are included.
arxiv  

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Detection of Ne VIII in an Intervening Multi-Phase Absorption System Towards 3C 263 [PDF]

open access: yes, 2009
We report on the detection of Ne VIII in an intervening multiphase absorption line system at z=0.32566 in the FUSE spectrum of the quasar 3C 263. The Ne VIII 770 A line detection has a 3.9 sigma significance. At the same velocity we also find absorption lines from C IV, O III, O IV and N IV. The line parameter measurements yield log [N(Ne VIII), cm^-2]
arxiv   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Dirac Neutrino Anapole Moment [PDF]

open access: yes, 2002
We calculate the Dirac neutrino anapole moment (a_{\nu_l}) in the context of the Standard Model (SM) making use of the Dirac form factor F_D(q^2) introduced recently by J. Bernabeu, L. G. Cabral-Rosetti, J. Papavassiliou y J. Vidal by using the Pinch Technique (PT) formalism, working in two different gauge-fixing schemes (R_\xi guage and the ...
arxiv   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

An Exploratory Study of Critical Factors Affecting the Efficiency of Sorting Techniques (Shell, Heap and Treap) [PDF]

open access: yesAnn. Univ. Tibiscus Comp. Sci. Series VIII / 1 (2010), 163-172, 2012
The efficiency of sorting techniques has a significant impact on the overall efficiency of a program. The efficiency of Shell, Heap and Treap sorting techniques in terms of both running time and memory usage was studied, experiments conducted and results subjected to factor analysis by SPSS.
arxiv  

Deuteron Electromagnetic Properties with a Poincaré-Covariant Current Operator within Front-Form Hamiltonian Dynamics [PDF]

open access: yes, 2001
Deuteron elastic and deep inelastic electromagnetic properties have been studied within the front-form Hamiltonian dynamics, using a Poincar\'e-covariant current operator. The deuteron elastic form factors are strongly sensitive to different realistic $N-N$ interactions, while the relevance of different nucleon form factor models is huge for $A(Q^2 ...
arxiv   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

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