Results 41 to 50 of about 14,336,962 (399)

N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice

Haematologica, 2018
Immune responses to factor VIII remain the greatest complication in the treatment of severe hemophilia A. Recent epidemiological evidence has highlighted that recombinant factor VIII produced in baby hamster kidney cells is more immunogenic than factor ...
Jesse D. Lai, Laura L. Swystun, Dominique Cartier, Kate Nesbitt, Cunjie Zhang, Christine Hough, James W. Dennis, David Lillicrap   +7 more
doaj   +1 more source

Factor VIII activity and bleeding risk during prophylaxis for severe hemophilia A: a population pharmacokinetic model

Haematologica, 2020
During factor VIII prophylaxis for severe hemophilia A, bleeding risk increases with time when factor VIII activity is below 1%. Maintaining trough activity above 1% does not protect all patients from bleeding.
Andreas Tiede, Faraizah Abdul Karim, Victor Jiménez-Yuste, Robert Klamroth, Sandra Lejniece, Takashi Suzuki, Andreas Groth, Elena Santagostino   +7 more
doaj   +1 more source

Angiogenesis in Squamous Cervical Neoplasia: Comparative Study of two Endothelial Cells [PDF]

, 2001
Purpose: to compare the efficiency of anti-factor VIII and anti-CD34 antibodies as vascular makers in cervical cancer, in cervical intraepithelial neoplasia and in normal cervix.
Baracat, Edmund Chada, Calux, Nilciza Maria De Carvalho Tavares, Focchi, João Norberto Stávale Jose, Lima, Geraldo Rodrigues De, Ribalta, Julisa Chamorro Lascasas   +4 more
core   +5 more sources

Imbalance of pro- vs. anti-coagulation factors in Chinese patients with Budd-Chiari syndrome and non-cirrhotic portal vein thrombosis. [PDF]

PLoS ONE, 2015
The coagulation abnormalities in non-cirrhotic Budd-Chiari syndrome (NC-BCS) and non-cirrhotic portal vein thrombosis (NC-PVT) are unclear. We conducted this case-control study to investigate the coagulation profile of NC-BCS and NC-PVT in Chinese ...
Hui Chen, Lei Liu, Xingshun Qi, Chuangye He, Zhanxin Yin, Feifei Wu, Daiming Fan, Guohong Han   +7 more
doaj   +1 more source

Acquired hemophilia A in the setting of dual anticoagulation therapy and lupus anticoagulant: a case report

Journal of Medical Case Reports, 2022
Background Acquired hemophilia A is a disorder caused by autoantibodies against coagulation factor VIII that may present with severe bleeding. We report a rare case of acquired hemophilia A presenting with coexisting lupus anticoagulant.
Victor Chen, Lauren C. Roby, Stephanie Wentzel, Mingjia Li, Nicholas Jones   +4 more
doaj   +1 more source

Minimal dataset for post-registration surveillance of new drugs in hemophilia: communication from the SSC of the ISTH [PDF]

, 2017
Clinical ...
Collins, P., Iorio, A., Lillicrap, D., Makris, M., Peyvandi, F., Pipe, S.W., Rosendaal, F.R., Subcomm Factor VIII Factor IX   +7 more
core   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Correction of coagulation in the hemophilic dog by transplantation of lymphatic tissue [PDF]

, 1974
Available data concerning the non-hepatic source of plasma factor VIII are conflicting. In the present study, dogs with factor VIII deficiency hemophilia were transplanted with spleen or vascularized lymph node grafts obtained from normal donor dogs ...
Björkén, C, Geis, WP, Groth, CG, Gustafsson, A, Hathaway, WE, Porter, KA, Putnam, CW, Starzl, TE   +7 more
core  

Suzaku Reveals Helium-burning Products in the X-ray Emitting Planetary Nebula BD+303639 [PDF]

, 2006
BD+303639, the brightest planetary nebula at X-ray energies, was observed with Suzaku, an X-ray observatory launched on 2005 July 10. Using the X-ray Imaging Spectrometer, the K-lines from C VI, O VII, and O VIII were resolved for the first time, and C/O,
Cahn J., de Freitas Pacheco J. A., H. Matsumoto, H. Murakami, J. Kotoku, K. Arnaud, K. Hamaguchi, K. Hayashida, K. Makishima, K. Matsushita, Kreysing H. C., Leuenhagen U., M. Kokubun, M. Murashima, Volk K.   +14 more
core   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source